[Study on preparation of konjac glucomannan-hydroxypropyl methyl cellulose compression coated tablets for colonic delivery and in vitro release]

[Study on preparation of konjac glucomannan-hydroxypropyl methyl cellulose compression coated tablets for colonic delivery and in vitro release] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Study on preparation of konjac glucomannan-hydroxypropyl methyl cellulose compression coated tablets for colonic delivery and in vitro release] Abstract Text:

Yu Zhang,Shi-xiang Hou,Yi Lu,Gang Chen,Jing-hong Ju,

OBJECTIVE: Prepare konjac glucomannan-hydroxypropyl methyl cellulose (HPMC) compression coated tablets and study the effects of the formulation, technics and in vitro dissolution condition on drug release behavior to elevate the colon-specific effects of preparation. METHOD: Berberine hydrochloride core tablets were prepared by wet granulation technique and konjac glucomannan-HPMC mixture as the coating layer were used with compression coated technique. The effects of the formulation and technics on drug release behavior were investigated by dissolution test. The erosion of coat layer during dissolution test was investigated. RESULT: Drug almost not released in dissolution medium stimulating gastric and intestinal condition, and released completely by coating layer erosion and rupture by enzyme in stimulating colonic condition. Drug release decreased with decreasing the ratio of konjac glucomannan-HPMC and increasing coat weight (P < 0.05), compression force was not found to be a significant factor on drug release. Drug release increased with increasing the concentration of beta-mannase in dissolution medium (P < 0.05), rotation speed has no effect on drug release. The release of drug was correlative with erosion of coat layer. The mechanism of drug release were diffusion and erosion. CONCLUSION: The konjac glucomannan-HPMC compression coated tablets was a promising delivery system for drugs to be delivered to the colon.

[Study on preparation of konjac glucomannan-hydroxypropyl methyl cellulose compression coated tablets for colonic delivery and in vitro release] Publishing Authors By Initials

Y Zhang,SX Hou,Y Lu,G Chen,JH Ju,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Study on preparation of konjac glucomannan-hydroxypropyl methyl cellulose compression coated tablets for colonic delivery and in vitro release] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazh

VOLUME: 31

Page Numbers: 642-5

Journal Abbreviation:

ISSN: 1001-5302

DAY: 11

MONTH: Apr

YEAR: 2006

[Study on preparation of konjac glucomannan-hydroxypropyl methyl cellulose compression coated tablets for colonic delivery and in vitro release] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 8913656

[Study on preparation of konjac glucomannan-hydroxypropyl methyl cellulose compression coated tablets for colonic delivery and in vitro release] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Study on preparation of konjac glucomannan-hydroxypropyl methyl cellulose compression coated tablets for colonic delivery and in vitro release] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Study on preparation of konjac glucomannan-hydroxypropyl methyl cellulose compression coated tablets for colonic delivery and in vitro release]

AFFILIATION: West China School of Pharmacy, Sichuan University, Chengdu.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Zhongguo Zhong Yao Za Zhi

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Study on preparation of konjac glucomannan-hydroxypropyl methyl cellulose compression coated tablets for colonic delivery and in vitro release Related Publications

• 3'-O-modified nucleotides as reversible terminators for pyrosequencing.
• A disposable two-throughput electrochemical immunosensor chip for simultaneous multianalyte determination of tumor markers.
• A novel strategy to increase heating efficiency in a split-focus ultrasound phased array.
• A regulatory T cell-dependent novel function of CD25 (IL-2Ralpha) controlling memory CD8(+) T cell homeostasis.
• Amperometric glucose sensor based on catalytic reduction of dissolved oxygen at soluble carbon nanofiber.
• An in vitro study on the involvement of LINGO-1 and Rho GTPases in Nogo-A regulated differentiation of oligodendrocyte precursor cells.
• Butyrolactone I reversibly alters nuclear configuration, periooplasmic microtubules and development of porcine oocytes.
• Channel and substrate zone two-dimensional resolution for chemiluminescent multiplex immunoassay.
• Chronic electrical stimulation of four acupuncture points on rat diabetic neuropathy.
• Combinatorial fluorescence energy transfer molecular beacons for probing nucleic acid sequences.
• Delayed rupture of pre-existing cerebral aneurysm in a young patient with minor head trauma.
• Effects of topography on simulated net primary productivity at landscape scale.
• Effects of water restrictions on the physiological parameters, psychological behavior and brain c-Fos expression in rats.
• Highly sensitive flow injection detection of hydrogen peroxide with high throughput using a carbon nanofiber-modified electrode.
• Large functional repertoire of regulatory T-cell suppressible autoimmune T cells in scurfy mice.
• Multiplex single-nucleotide polymorphism detection by combinatorial fluorescence energy transfer tags and molecular affinity.
• Nerve Cell Segmentation via Multi-Scale Gradient Watershed Hierarchies.
• Prostaglandin I(2) and E(2) mediate the protective effects of cyclooxygenase-2 in a mouse model of immune-mediated liver injury.
• Removing Eye Movement and Power Line Artifacts from the EEG based on ICA.
• Role of neutrophils in a mouse model of halothane-induced liver injury.
• Salt and drought tolerance of transgenic salvia miltiorrhiza Bunge with the TaLEA1 gene.
• Systematic analysis of microRNA expression of RNA extracted from fresh frozen and formalin-fixed paraffin-embedded samples.
• The type I Lanyu pig has a maternal genetic lineage distinct from Asian and European pigs.
• Utilization of rehabilitation therapies by nursing home residents with MS at admission.
• [Effect of three ways of nutritional education on knowledge-attitude-behavior with nutrition in pupils]
• [Efficacy of total removal or subtotal removal combined gamma knife radiation on giant pituitary adenoma: a report of 160 cases]
• [Post-anesthetic autologous blood donation used in knee and hip arthroplasty]
• [Pseudo-parasitism of Limax flavus in stomach]
• [Study on preparation of konjac glucomannan-hydroxypropyl methyl cellulose compression coated tablets for colonic delivery and in vitro release]
• [The study of molecular imaging should be strengthen]