[Study on making pneumoconiosis model and method of lung lavage in rabbit]

[Study on making pneumoconiosis model and method of lung lavage in rabbit] Research Abstract Details 

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[Study on making pneumoconiosis model and method of lung lavage in rabbit] Abstract Text:

Dong Xu,Yiming Wu,Peng Wang,Yubao Xu,Aimin Meng,Hong Li,Zhangxian Liu,Ran Zhu,

OBJECTIVE: To provide an intact rabbit pneumoconiosis model and a method of lung lavage for studying the pathogenesis and treatment of pneumoconiosis. METHODS: The dust particles(< or = 5 microns diameter) were poured into the trachea of rabbit by trachea spile. The lung lavage of rabbit was carried out by the improved trachea catheter method. RESULTS: The rabbit lungs exposed to coal dust showed many black dust spots and there were proliferation of fibroblasts. The rabbit lungs exposed to silica dust showed nodules and several fusing nodules. The X-ray film showed that there were small irregular shadows, or fusing together into flake-like or round shadows in both lungs. The recovery rate of the lung lavage was 89%-94%. CONCLUSION: The model made by trachea spile and the method of lung lavage by the improved trachea catheter were simple, safe and without being injured.

[Study on making pneumoconiosis model and method of lung lavage in rabbit] Publishing Authors By Initials

D Xu,Y Wu,P Wang,Y Xu,A Meng,H Li,Z Liu,R Zhu,

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[Study on making pneumoconiosis model and method of lung lavage in rabbit] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Z

VOLUME: 20

Page Numbers: 131-3

Journal Abbreviation: Zhonghua Lao Dong Wei Sheng Zh

ISSN: 1001-9391

DAY: 25

MONTH: Apr

YEAR: 2002

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LANGUAGE: chi

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AFFILIATION: Department of Occupational Health and Toxicology, Zhengzhou University, Zhengzhou, 450052, China.

Country: China

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MEDLINETA: Zhonghua Lao Dong Wei Sheng Zh

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