Study on chiral resolution of three beta-blockers by affinity electrokinetic chromatography.

Study on chiral resolution of three beta-blockers by affinity electrokinetic chromatography. Research Abstract Details 

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Study on chiral resolution of three beta-blockers by affinity electrokinetic chromatography. Abstract Text:

Guoqiang Yang,Yifang Zhao,Meixian Li,Zhiwei Zhu,Qiankun Zhuang,

The chiral resolution of three beta-blockers including propranolol, pindolol and oxprenolol, was studied by affinity electrokinetic chromatography. The effect of various chiral selectors and some key parameters including buffer pH, buffer concentration, capillary temperature and applied voltage were carefully studied, respectively. At optimum condition, based on the signal-to-noise ratio of 3, the detection limits for the simple resolution and chiral resolution were found to be 1.0x10(-5) and 4.0 x 10(-5)M, respectively. In addition, the interactions of these beta-blockers with bovine serum albumin (BSA) were studied and the binding constant (K(a)) between BSA and each of beta-blockers were calculated. Based on linear correlation coefficient, it can be concluded that the binding ratio of pindolol (oxprenolol) combining with BSA is 1:1, and that the binding number of propranolol interacting with BSA deviates one.

Study on chiral resolution of three beta-blockers by affinity electrokinetic chromatography. Publishing Authors By Initials

G Yang,Y Zhao,M Li,Z Zhu,Q Zhuang,

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Study on chiral resolution of three beta-blockers by affinity electrokinetic chromatography. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Talanta

VOLUME: 75

Page Numbers: 222-6

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ISSN: 1873-3573

DAY: 17

MONTH: 11

YEAR: 2007

Study on chiral resolution of three beta-blockers by affinity electrokinetic chromatography. Information

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LANGUAGE: eng

NlmUniqueID: 2984816

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Grant and Affiliation Information for Study on chiral resolution of three beta-blockers by affinity electrokinetic chromatography.

AFFILIATION: Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, PR China.

Country: England

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MEDLINETA: Talanta

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