Study on a nanoparticle system for buccal delivery of insulin.

Study on a nanoparticle system for buccal delivery of insulin. Research Abstract Details 

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Study on a nanoparticle system for buccal delivery of insulin. Abstract Text:

Yong Luo,Huibi Xu,Kaixun Huang,Zhonghong Gao,Hong Peng,Xiqun Sheng,

In this paper, a nanoparticle system of insulin (NSI) was prepared for buccal transmucosal delivery of insulin. The average size of the suspending particles was 67.5 nm, and a possible microstructure of the nanoparticles in the system was proposed. The transmucosal ability of insulin was evaluated in rabbits from the views of the hypoglycaemic rate and pharmacokinetics. The average bioavailability of NSI by buccal delivery versus subcutaneous injection is 18.3%. These results indicate that the studied nanoparticle system may be promising vehicles for the buccal delivery of insulin.

Study on a nanoparticle system for buccal delivery of insulin. Publishing Authors By Initials

Y Luo,H Xu,K Huang,Z Gao,H Peng,X Sheng,

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Study on a nanoparticle system for buccal delivery of insulin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Conference proceedings : ... Annual International

VOLUME: 5

Page Numbers: 4842-5

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ISSN: 1557-170X

DAY: 6

MONTH: 02

YEAR: 2005

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LANGUAGE: eng

NlmUniqueID: 101243413

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Grant and Affiliation Information for Study on a nanoparticle system for buccal delivery of insulin.

AFFILIATION: Dept. of Chem., Huazhong Univ. of Sci. & Technol., Wuhan.

Country: United States

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MEDLINETA: Conf Proc IEEE Eng Med Biol So

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