Study of the genotypic resistant pattern in HIV-infected women and children from rural west Cameroon.

Study of the genotypic resistant pattern in HIV-infected women and children from rural west Cameroon. Research Abstract Details 

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Study of the genotypic resistant pattern in HIV-infected women and children from rural west Cameroon. Abstract Text:

The distribution of antiretroviral (ARV) therapy resistance mutations among HIV-1 strains was evaluated in 39 postpartum women, one pregnant woman, and 12 HIV-positive babies (seven newborns and five children) living in rural west Cameroon. Thirty-five women and all newborns received a single dose of nevirapine (NVP) to prevent mother-to-child transmission of HIV-1; two women were ARV treated and three were ARV naive. Of the 52 viral strains examined, three were subtype B, 45 were classified into eight HIV-1 non-B subtypes, and four remained unclassifiable. Sequence analysis for genotypic drug resistance in the reverse transcriptase (RT) gene showed the presence of mutations associated with nonnucleoside RT inhibitor resistance in 20% of the samples from NVP-treated women and in 57% of those from treated newborns. Mutations associated with nucleoside RT inhibitors (M184V in one case and V118I in four cases) were found in five samples, despite being derived from ARV-naive patients. As expected, a greater frequency of mutations was found in the protease gene region. Of the sequences analyzed, 79% harbored five to seven specific mutations. The secondary mutations showed the typical protease inhibitor resistance-associated pattern for non-subtype B viruses, M36I being the predominant mutation (92.5% in women, 100% in babies). Other mutations frequently detected were K20I, L63P, H69K, and I13V. These findings confirm that resistance mutations can be detected in ARV-naive patients infected with non-B subtypes and emphasize an urgent need for studies assessing the impact of these mutations on the efficacy of subsequent ARV therapy and on the appearance of drug-resistant strains.

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Study of the genotypic resistant pattern in HIV-infected women and children from rural west Cameroon. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: AIDS research and human retroviruses

VOLUME: 24

Page Numbers: 781-5

Journal Abbreviation: AIDS Res. Hum. Retroviruses

ISSN: 1931-8405

DAY: 19

MONTH: Jun

YEAR: 2008

Study of the genotypic resistant pattern in HIV-infected women and children from rural west Cameroon. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Study of the genotypic resistant pattern in HIV-infected women and children from rural west Cameroon.

AFFILIATION: Department of Experimental Medicine, Virology Section, Sapienza University of Rome, Rome, Italy. ombretta.turriziani@uniroma1.it

Country: United States

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MEDLINETA: AIDS Res Hum Retroviruses

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