Study of superoxide dismutase's expression in the colon produced by azoxymethane and inositol hexaphosfate's paper, in mice.

Study of superoxide dismutase's expression in the colon produced by azoxymethane and inositol hexaphosfate's paper, in mice. Research Abstract Details 

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Study of superoxide dismutase's expression in the colon produced by azoxymethane and inositol hexaphosfate's paper, in mice. Abstract Text:

do Amaral, Fagundes,Guido Marks,Celso Massachi Inouye, Amaral, Fagundes,Guido Marks,Celso Massachi Inouye,

PURPOSE: To investigate the expression of superoxide dismutase (SOD), with use of antioxidant inositol hexaphosfate, in the presence of the carcinogen azoxymethane, in FCA of colon rats. METHODS: Wistar rats (n=48) were distributed in four groups of 12 mice. Divided in control (n=12); with azoxymethane administration AOM (n=12); administration of IP6 (n=12) and with administration of IP6/AOM (n=12). The subcutaneous administration of azoxymethane happened in the week 3 and 4 of the experiment, in dose 20 mg/Kg, weekly; and administration of IP6 to 1% in water of drinking for 6 weeks in the group 3 and 4. The identification of the expression SOD-1 was accomplished through the quantification imunohistochemistry by the image processing attended by computer in crypts and focus of aberrant crypts in right colon. RESULTS: The group control presented expression of SOD1, on average 16.0%; group AOM, 26.7%; group IP6, 16.9%; group IP6/AOM, 20.9%. Variance analysis among the groups, was calculated 0.0078. CONCLUSION: The azoxymethane increase expression SOD1, while inositol hexaphosphate decreases in a significant way the expression of SOD1 promoted by the administration of the carcinogen azoxymethane.

Study of superoxide dismutase's expression in the colon produced by azoxymethane and inositol hexaphosfate's paper, in mice. Publishing Authors By Initials

EG do Amaral,DJ Fagundes,G Marks,CM Inouye,EG Amaral,DJ Fagundes,G Marks,CM Inouye,

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Study of superoxide dismutase's expression in the colon produced by azoxymethane and inositol hexaphosfate's paper, in mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta cirúrgica brasileira / Sociedade Brasileira p

VOLUME: 21 Suppl 4

Page Numbers: 27-31

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ISSN: 0102-8650

DAY: 12

MONTH: 02

YEAR: 2006

Study of superoxide dismutase's expression in the colon produced by azoxymethane and inositol hexaphosfate's paper, in mice. Information

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LANGUAGE: eng

NlmUniqueID: 9103983

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AFFILIATION: Department of Surgery, Federal University of Mato Grosso do Sul, Brazil.

Country: Brazil

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MEDLINETA: Acta Cir Bras

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