Study of Cell-mediated Response in Mice by HPV16 L1 Virus-like Particles Expressed in Saccharomyces cerevisiae.

Study of Cell-mediated Response in Mice by HPV16 L1 Virus-like Particles Expressed in Saccharomyces cerevisiae. Research Abstract Details 

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Study of Cell-mediated Response in Mice by HPV16 L1 Virus-like Particles Expressed in Saccharomyces cerevisiae. Abstract Text:

Mi-Kyung Woo,Sook-Jin Hur,Suenie Park,Hong-Jin Kim,Mi-Kyung Woo,Sook-Jin Hur,Suenie Park,Hong-Jin Kim,

The first vaccine against human papillomaviruses (HPV) formulated with HPV16 L1 virus-like particles (VLPs) produced in yeast was approved by the FDA in June 2006. Nevertheless, there have been few studies of the immunogenicity in mice of VLPs. In this study, we evaluated the cell-mediated immune response to VLPs produced in Saccharomyces cerevisiae. After immunization of mice with HPV16 L1 VLPs, we measured splenocytes proliferation and the levels of IFNgamma, IL2, IL4, and IL5. Splenocytes proliferation was significantly increased and a mixed Th1/Th2 response was indicated. IgG subtype immunoresponses were strongly induced and IgG1 titers were higher than those of IgG2a.

Study of Cell-mediated Response in Mice by HPV16 L1 Virus-like Particles Expressed in Saccharomyces cerevisiae. Publishing Authors By Initials

MK Woo,SJ Hur,S Park,HJ Kim,MK Woo,SJ Hur,S Park,HJ Kim,

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Study of Cell-mediated Response in Mice by HPV16 L1 Virus-like Particles Expressed in Saccharomyces cerevisiae. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of microbiology and biotechnology

VOLUME: 17

Page Numbers: 1738-41

Journal Abbreviation: J. Microbiol. Biotechnol.

ISSN: 1017-7825

DAY: 24

MONTH: Oct

YEAR: 2007

Study of Cell-mediated Response in Mice by HPV16 L1 Virus-like Particles Expressed in Saccharomyces cerevisiae. Information

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LANGUAGE: eng

NlmUniqueID: 9431852

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Grant and Affiliation Information for Study of Cell-mediated Response in Mice by HPV16 L1 Virus-like Particles Expressed in Saccharomyces cerevisiae.

AFFILIATION: College of Pharmacy, Chung Ang University, Seoul 156-756, Korea.

Country: Korea (South)

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MEDLINETA: J Microbiol Biotechnol

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