[Study of C807T polymorphism of the platelet collagen receptor alpha2 gene coding sequence in Suzhou Han population]

[Study of C807T polymorphism of the platelet collagen receptor alpha2 gene coding sequence in Suzhou Han population] Research Abstract Details 

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[Study of C807T polymorphism of the platelet collagen receptor alpha2 gene coding sequence in Suzhou Han population] Abstract Text:

J Shi,W Gao,X Bai,Z Wang,C Ruan,

OBJECTIVE: To study the C807T polymorphism of the platelet collagen receptor alpha(2) gene coding sequence in Suzhou Han population. This polymorphism was associated with the expression density of integrin alpha(2)beta(1) on the platelet surface. METHODS: An amplified 1332 bp fragment of human alpha(2) gene from 110 unrelated individuals was analyzed by Bgl II and Ase I restriction assay. The resulting products were electrophoresed in 8% polyacrylamide gels and stained with ethidium bromide. RESULTS: The allelic frequencies were 0.291:0.709 for T807 allele: C807 allele in Suzhou Han population. The total theoretical heterozygous rate was 41%. The genotypic frequencies were 0.018:0.546:0.436 for homozygous 807T allele: heterozygous 807C/T allele: homozygous 807C allele. CONCLUSION: The C807T polymorphism of the platelet collagen receptor alpha2 gene in Suzhou Han population was different from that observed in other populations.

[Study of C807T polymorphism of the platelet collagen receptor alpha2 gene coding sequence in Suzhou Han population] Publishing Authors By Initials

J Shi,W Gao,X Bai,Z Wang,C Ruan,

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[Study of C807T polymorphism of the platelet collagen receptor alpha2 gene coding sequence in Suzhou Han population] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 22

Page Numbers: 125-7

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 5

MONTH: Mar

YEAR: 2001

[Study of C807T polymorphism of the platelet collagen receptor alpha2 gene coding sequence in Suzhou Han population] Information

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LANGUAGE: chi

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AFFILIATION: Thrombosis and Hemostasis Research Unit, Jiangsu Institute of Hematology, The First Affiliated Hospital, Suzhou University, Suzhou 215006, China.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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