[Study of adiponectin expression in placenta and its correlation with preeclampsia]

[Study of adiponectin expression in placenta and its correlation with preeclampsia] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Study of adiponectin expression in placenta and its correlation with preeclampsia] Abstract Text:

OBJECTIVE: To investigate the expression of adiponectin in placenta and its correlation with preeclampsia. METHODS: Placental tissues were collected from normal term pregnancies (normal pregnancy group, n = 20), mild preeclampsia (mild preeclampsia group, n = 12) and severe preeclampsia (severe preeclampsia group, n = 22). The expression of adiponectin protein and the intensity of its mRNA in placenta were detected using immunohistochemistry and RT-PCR, respectively. Integral optical density (IOD) which represents the expression level of adiponectin protein, and the ratio of adiponectin cDNA PCR products to beta-actin cDNA PCR products which represents the intensity of transcription of adiponectin mRNA in placenta were analyzed. RESULTS: (1) The expression of adiponectin protein was observed in cytoplasm of placental cytotrophoblasts and syncytiotrophoblasts among three groups. There was no significant difference in adiponectin protein expression between maternal side and fetal side of placenta in three groups (all P > 0.05); (2) The expression of adiponectin protein in placenta in severe preeclampsia group (30 984 +/- 14 604) was significantly lower than that of mild preeclampsia group (58 360 +/- 8910, P < 0.01) and of normal pregnancy group (53 246 +/- 17 554, P < 0.01). There was also no significant difference in the expression of adiponectin protein in placenta between term delivery and preterm delivery in severe preeclampsia group (38 890 +/- 20 386 vs 29 319 +/- 8997, P > 0.05), however, the expression of adiponectin protein in placenta in term delivery of severe preeclampsia group was significantly lower than that of term delivery of normal pregnancy group (38 890 +/- 20 386 vs 53 246 +/- 17 554, P < 0.05); (3) The expression of adiponectin mRNA was detected in placental tissues among three groups also. The intensity of transcription of adiponectin in placenta in severe preeclampsia group (1.0 +/- 0.2) was markedly lower than that of mild preeclampsia group (2.9 +/- 0. 8, P < 0.05) and normal pregnancy group (3.3 +/- 1.1, P = 0.000). CONCLUSION: The expression of adiponectin decreases in placenta tissues of severe preeclampsia, indicating that the abnormal expression of adiponectin may be involved in the pathogenesis of preeclampsia.

[Study of adiponectin expression in placenta and its correlation with preeclampsia] Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Study of adiponectin expression in placenta and its correlation with preeclampsia] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua fu chan ke za zhi

VOLUME: 43

Page Numbers: 90-3

Journal Abbreviation: Zhonghua Fu Chan Ke Za Zhi

ISSN: 0529-567X

DAY: 7

MONTH: Feb

YEAR: 2008

[Study of adiponectin expression in placenta and its correlation with preeclampsia] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 16210370

[Study of adiponectin expression in placenta and its correlation with preeclampsia] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Study of adiponectin expression in placenta and its correlation with preeclampsia] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Study of adiponectin expression in placenta and its correlation with preeclampsia]

AFFILIATION: Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Zhonghua Fu Chan Ke Za Zhi

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Study of adiponectin expression in placenta and its correlation with preeclampsia Related Publications

• Non-rectangular waveforms for neural stimulation with practical electrodes.
• Simultaneous determination of four water-soluble vitamins in fortified infant foods by ultra-performance liquid chromatography coupled with triple quadrupole mass spectrometry.
• [Arsenic contents in native copper]
• [Comparison of trace elements in muli before and after processing]
• [Study of adiponectin expression in placenta and its correlation with preeclampsia]