Studies on the pathogenicity of anaerobes, especially Prevotella bivia, in a rat pyometra model.

Studies on the pathogenicity of anaerobes, especially Prevotella bivia, in a rat pyometra model. Research Abstract Details 

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Studies on the pathogenicity of anaerobes, especially Prevotella bivia, in a rat pyometra model. Abstract Text:

H Mikamo,K Kawazoe,K Izumi,K Watanabe,K Ueno,T Tamaya,

OBJECTIVE: Prevotella bivia is one of the anaerobic bacteria that resides in the flora of the female genital tract. We studied the pathogenicity of P. bivia in a rat pyometra model. METHODS: The experimental animal (rat) model of pyometra was developed to investigate the pathogenicity of P. bivia in a rat pyometra model. RESULTS: In the groups inoculated with aerobes alone, the infection rate was 10% (1/10) in the Staphylococcus aureus- or Staphylococcus agalactiae-inoculated group and 20% (2/10) in the Escherichia coli-inoculated group. Infection was not established in the groups inoculated with anaerobes alone. High infection rates were observed in all the mixed-infection groups. In the S. agalactiae- and Bacteroides fragilis-, S. agalactiae- and P. bivia-, F. coli- and B. fragilis-, and E. coli- and P. bivia-inoculated groups, an infection rate of 100% (10/10) was demonstrated. The efficacy of antibiotics such as flomoxef (FMOX) could be determined using a rat pyometra model. In relation to the alteration of vaginal microbial flora during the menstrual cycle, estrogen increased the growth of P. bivia. CONCLUSION: Mixture of aerobic bacteria and P. bivia increased the pathogenicity of P. bivia. Estrogen would be useful for raising up the inflammatory change of the uterus in experimental models of genital tract infection due to P. bivia.

Studies on the pathogenicity of anaerobes, especially Prevotella bivia, in a rat pyometra model. Publishing Authors By Initials

H Mikamo,K Kawazoe,K Izumi,K Watanabe,K Ueno,T Tamaya,

For similar urogenital system: genitalia: genitalia, female: vagina research abstracts see: urogenital system: genitalia: genitalia, female: vagina research

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Studies on the pathogenicity of anaerobes, especially Prevotella bivia, in a rat pyometra model. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Infectious diseases in obstetrics and gynecology

VOLUME: 6

Page Numbers: 61-5

Journal Abbreviation: Infect Dis Obstet Gynecol

ISSN: 1064-7449

DAY: 21

MONTH: 01

YEAR: 1998

Studies on the pathogenicity of anaerobes, especially Prevotella bivia, in a rat pyometra model. Information

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LANGUAGE: eng

NlmUniqueID: 9318481

Studies on the pathogenicity of anaerobes, especially Prevotella bivia, in a rat pyometra model. Keywords Mesh Terms:

KEYWORDS: Vagina

MESH TERMS: microbiology

Chemical & Substance for Abstract: Studies on the pathogenicity of anaerobes, especially Prevotella bivia, in a rat pyometra model. Information

Substance Name: flomoxef

Registry Number: 92823-03-5

Grant and Affiliation Information for Studies on the pathogenicity of anaerobes, especially Prevotella bivia, in a rat pyometra model.

AFFILIATION: Department of Obstetrics and Gynecology, School of Medicine, Gifu University, Japan.

Country: UNITED STATES

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MEDLINETA: Infect Dis Obstet Gynecol

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