Studies on the nature and significance of connective tissue antibodies in adult coeliac disease and Crohn's disease.

Studies on the nature and significance of connective tissue antibodies in adult coeliac disease and Crohn's disease. Research Abstract Details 

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Studies on the nature and significance of connective tissue antibodies in adult coeliac disease and Crohn's disease. Abstract Text:

Sera from 92 patients with adult coeliac disease, 20 patients with Crohn's disease, and 89 control patients were tested for the presence and immunoglobulin class of anticonnective tissue antibodies. In adult coeliac disease patients taking a normal diet there was a high frequency of sera positive for connective tissue antibodies and the majority were IgA in class. Following gluten withdrawal, IgA class connective tissue antibody activity was strikingly reduced. No such antibody activity was detected in concentrated jejunal fluid collected from 15 patients with adult coeliac disease, seven of whose sera were positive for connective tissue antibody.Connective tissue antibody activity was not absorbed by fractions of gluten. Similarly, preparations of human reticulin and glomerular basement membrane together with elastin and collagen failed to absorb connective tissue antibody.

Studies on the nature and significance of connective tissue antibodies in adult coeliac disease and Crohn's disease. Publishing Authors By Initials

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Studies on the nature and significance of connective tissue antibodies in adult coeliac disease and Crohn's disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Gut

VOLUME: 15

Page Numbers: 284-8

Journal Abbreviation: Gut

ISSN: 0017-5749

DAY: 4

MONTH: Apr

YEAR: 1974

Studies on the nature and significance of connective tissue antibodies in adult coeliac disease and Crohn's disease. Information

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LANGUAGE: eng

NlmUniqueID: 2985108

Studies on the nature and significance of connective tissue antibodies in adult coeliac disease and Crohn's disease. Keywords Mesh Terms:

KEYWORDS: Reticulin

MESH TERMS: immunology

Chemical & Substance for Abstract: Studies on the nature and significance of connective tissue antibodies in adult coeliac disease and Crohn's disease. Information

Substance Name: Gluten

Registry Number: 8002-80-0

Grant and Affiliation Information for Studies on the nature and significance of connective tissue antibodies in adult coeliac disease and Crohn's disease.

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Country: ENGLAND

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MEDLINETA: Gut

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