STUDIES ON THE EXPRESSION LEVELS OF STEROL-METABOLIZING ENZYMES IN THE OBESE MODEL SHR/NDmcr-cp RATS.

STUDIES ON THE EXPRESSION LEVELS OF STEROL-METABOLIZING ENZYMES IN THE OBESE MODEL SHR/NDmcr-cp RATS. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

STUDIES ON THE EXPRESSION LEVELS OF STEROL-METABOLIZING ENZYMES IN THE OBESE MODEL SHR/NDmcr-cp RATS. Abstract Text:

Makiko Kudo,Mitsuhide Noshiro,Yuri Aoyama,Yuzo Yoshida,Makiko Kudo,Mitsuhide Noshiro,Yuri Aoyama,Yuzo Yoshida,

SUMMARY 1. Expression levels of four key enzymes of cholesterol metabolism, namely 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, lanosterol 14-demethylase (CYP51), cholesterol 7alpha-hydroxylase (CYP7A1) and sterol 12alpha-hydroxylase (CYP8B1), in metabolic syndrome model rats (SHR/NDmcr-cp) were examined. 2. Decreased expression of CYP51, which may be linked to the development of obesity, was found in the rats. 3. Expression of CYP8B1 was significantly higher in young rats. 4. No substantial change was observed in the mRNA levels of the dominant rate-limiting enzymes of sterol metabolism, namely HMG-CoA reductase and CYP7A1, in the rats. 5. These findings suggest that the expression levels of two key enzymes managing the downstream parts of the cholesterol-metabolizing pathways are altered in the rats, although little change was observed in the expression levels of the dominant rate-limiting enzymes of cholesterol metabolism.

STUDIES ON THE EXPRESSION LEVELS OF STEROL-METABOLIZING ENZYMES IN THE OBESE MODEL SHR/NDmcr-cp RATS. Publishing Authors By Initials

M Kudo,M Noshiro,Y Aoyama,Y Yoshida,M Kudo,M Noshiro,Y Aoyama,Y Yoshida,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

STUDIES ON THE EXPRESSION LEVELS OF STEROL-METABOLIZING ENZYMES IN THE OBESE MODEL SHR/NDmcr-cp RATS. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental pharmacology & physiolog

VOLUME: 31 Suppl 2

Page Numbers: S57-9

Journal Abbreviation: Clin. Exp. Pharmacol. Physiol.

ISSN: 0305-1870

DAY: 14

MONTH: Dec

YEAR: 2004

STUDIES ON THE EXPRESSION LEVELS OF STEROL-METABOLIZING ENZYMES IN THE OBESE MODEL SHR/NDmcr-cp RATS. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 425076

STUDIES ON THE EXPRESSION LEVELS OF STEROL-METABOLIZING ENZYMES IN THE OBESE MODEL SHR/NDmcr-cp RATS. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: STUDIES ON THE EXPRESSION LEVELS OF STEROL-METABOLIZING ENZYMES IN THE OBESE MODEL SHR/NDmcr-cp RATS. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for STUDIES ON THE EXPRESSION LEVELS OF STEROL-METABOLIZING ENZYMES IN THE OBESE MODEL SHR/NDmcr-cp RATS.

AFFILIATION: School of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.

Country: Australia

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Clin Exp Pharmacol Physiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

STUDIES ON THE EXPRESSION LEVELS OF STEROL-METABOLIZING ENZYMES IN THE OBESE MODEL SHR/NDmcr-cp RATS Related Publications

• "Watermelon rectum" associated with multiple vascular ectasia in the colon.
• A compact UHV X-ray diffractometer for studying surfaces and interfaces.
• Abnormal course of the oculomotor nerve on the clivus combined with a petroclival meningioma: case report.
• Application of independent component analysis and expansion matching filter for automatic detection of motor unit action potential trains.
• Application of near-infrared spectroscopy to measuring of attractiveness of opposite-sex faces.
• Binding sites on laminin receptors as components for antibiotics.
• CYP17 polymorphism and tamoxifen-induced hepatic steatosis.
• Chromosomal abnormalities subdivide neuroepithelial tumors into clinically relevant groups.
• Clear cell hidradenoma of the breast: a case report with review of the literature.
• Clinical characteristics of hypotonia: a survey of pediatric physical and occupational therapists.
• Detection of high concentrations of 137Cs in Walleye pollock collected in the Sea of Japan.
• Efficacy of recombinant annexin 2 for fibrinolytic therapy in a rat embolic stroke model: a magnetic resonance imaging study.
• Electrochemical generation of glycosyl triflate pools.
• Electron microscopic examination of the dormant spore and the sporulation of Paenibacillus motobuensis strain MC10.
• Experimental and analytical investigations of motor unit location for the precise estimation of muscle force with surface electromyograms.
• F1-ATPase rotates by an asymmetric, sequential mechanism using all three catalytic subunits.
• Feasibility of oxaliplatin and infusional fluorouracil/leucovorin (FOLFOX4) for Japanese patients with unresectable metastatic colorectal cancer.
• Fully Automated Three-Dimensional Detection of Polyps in Fecal-Tagging CT Colonography.
• Iatrogenic perforation associated with therapeutic colonoscopy: a multicenter study in Japan.
• Insufficient outcomes with imatinib mesylate: case report of Ph-positive acute myeloid leukemia evolving from myelodysplastic syndrome.
• Interferential current stimulation for sensory communication between prosthetic hand and man.
• Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury.
• Photoactivated ethidium monoazide directly cleaves bacterial DNA and is applied to PCR for discrimination of live and dead bacteria.
• Protein kinase C delta activates IkappaB-kinase alpha to induce the p53 tumor suppressor in response to oxidative stress.
• Recovery of olfactory function after an anterior craniofacial approach.
• Retrospective review of pediatric and adult autoimmune hepatitis in two quaternary care centres in British Columbia: increased prevalence seen in British Columbia's First Nations community.
• STUDIES ON THE EXPRESSION LEVELS OF STEROL-METABOLIZING ENZYMES IN THE OBESE MODEL SHR/NDmcr-cp RATS.
• Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
• Surface modification of poly(ethylene terephthalate) by plasma polymerization of poly(ethylene glycol).
• Varicella zoster virus meningoencephalitis accompanied by sporadic skin lesions in an older immunocompetent adult.