Studies on rat liver catalase. X. Effect of hemin and an inhibitor on the translation of catalase messenger RNA1.

Studies on rat liver catalase. X. Effect of hemin and an inhibitor on the translation of catalase messenger RNA1. Research Abstract Details 

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Studies on rat liver catalase. X. Effect of hemin and an inhibitor on the translation of catalase messenger RNA1. Abstract Text:

T Sakamoto,T Higashi,

Rat liver catalase mRNA was translated in a rabbit reticulocyte lysates and wheat germ cell-free system in the presence or absence of hemin and/or a translational inhibitor prepared from reticulocytes, liver cells, and wheat germs. Failure to add hemin to the lysates, or the addition of a hemin-regulated translational inhibitor (HRI) to the hemin-supplemented lysates caused a repressed translation. A preparation of inhibitor from rat liver showed activity similar to that of HRI for this translating system. The translation repression by rat liver inhibitor was reversed by eIF-2 (initiation factor) or GTP, but ATP enhanced the repression. The translation of catalase mRNA in the wheat germ system was not affected by the addition of hemin. An inhibitor prepared from wheat germ extracts, as well as the rat liver inhibitor, markedly decreased the rate of translation. eIF-2, GTP, and ATP behaved in the manner described above. Catalase synthesis in a cell-free system derived from rat liver (using endogenous mRNA) was not influenced by either hemin or the inhibitor. The possibilities are discussed that the synthesis of catalase in liver cells is controlled by a translational inhibitor at the level of chain initiation, and that the formation of the inhibitor from its inactive proinhibitor is regulated by the amount of heme.

Studies on rat liver catalase. X. Effect of hemin and an inhibitor on the translation of catalase messenger RNA1. Publishing Authors By Initials

T Sakamoto,T Higashi,

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Studies on rat liver catalase. X. Effect of hemin and an inhibitor on the translation of catalase messenger RNA1. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 85

Page Numbers: 389-96

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Feb

YEAR: 1979

Studies on rat liver catalase. X. Effect of hemin and an inhibitor on the translation of catalase messenger RNA1. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Studies on rat liver catalase. X. Effect of hemin and an inhibitor on the translation of catalase messenger RNA1. Keywords Mesh Terms:

KEYWORDS: Triticum

MESH TERMS: physiology

Chemical & Substance for Abstract: Studies on rat liver catalase. X. Effect of hemin and an inhibitor on the translation of catalase messenger RNA1. Information

Substance Name: Catalase

Registry Number: EC 1.11.1.6

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Country: JAPAN

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MEDLINETA: J Biochem

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