Studies on nerve cell affinity of biodegradable modified chitosan films.

Studies on nerve cell affinity of biodegradable modified chitosan films. Research Abstract Details 

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Studies on nerve cell affinity of biodegradable modified chitosan films. Abstract Text:

Mingyu Cheng,Wenling Cao,Yuan Gao,Yandao Gong,Nanming Zhao,Xiufang Zhang,

Chitosan, a natural polysaccharide that has excellent biocompatibility and biodegradability, can be used as nerve conduit material. The purpose of this work was to study the ability of chitosan and some chitosan-derived materials to facilitate nerve cell attachment, differentiation and growth. The biomaterials studied were chitosan, poly-L-lysine-blended chitosan (CP), collagen-blended chitosan (CC) and albumin-blended chitosan (CA), with collagen control material. Culture of PC12 cells and fetal mouse cerebral cortex (FMCC) cells on these biomaterials was used to evaluate their nerve cell affinity. The composite materials, including CP, CC and CA, had significantly improved nerve cell affinity compared to chitosan, as established by increasing attachment, differentiation and growth of PC12 cells. FMCC cells could also grow better on composite materials than on chitosan. CP exhibited the best nerve cell affinity among these three types of composite material. CP is an even better material in promoting neurite outgrowth than collagen, a substrate that is widely used in tissue engineering, suggesting that CP is a promising candidate material for nerve regeneration.

Studies on nerve cell affinity of biodegradable modified chitosan films. Publishing Authors By Initials

M Cheng,W Cao,Y Gao,Y Gong,N Zhao,X Zhang,

For similar water research abstracts see: water research

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Studies on nerve cell affinity of biodegradable modified chitosan films. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 14

Page Numbers: 1155-67

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 2003

Studies on nerve cell affinity of biodegradable modified chitosan films. Information

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LANGUAGE: eng

NlmUniqueID: 9007393

Studies on nerve cell affinity of biodegradable modified chitosan films. Keywords Mesh Terms:

KEYWORDS: Water

MESH TERMS: chemistry

Chemical & Substance for Abstract: Studies on nerve cell affinity of biodegradable modified chitosan films. Information

Substance Name: Chitosan

Registry Number: 9012-76-4

Grant and Affiliation Information for Studies on nerve cell affinity of biodegradable modified chitosan films.

AFFILIATION: Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China.

Country: Netherlands

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MEDLINETA: J Biomater Sci Polym Ed

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