[Studies on immunoprotection in mice after immunization with Schistosoma japonicum 22.6 kDa recombinant protein]

[Studies on immunoprotection in mice after immunization with Schistosoma japonicum 22.6 kDa recombinant protein] Research Abstract Details 

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[Studies on immunoprotection in mice after immunization with Schistosoma japonicum 22.6 kDa recombinant protein] Abstract Text:

C Su,L Ma,R Wang,X Hu,S Chen,L Shao,H Wu,L Shen,Z Zhang,G Wu,

AIM: To evaluate the immunoprotective effect of Schistosoma japonicum recombinant 22.6 kDa (rSj22.6) and Sj22.6/Sj26 GST fusion protein. METHODS: The Sj22.6/Sj26 GST fusion protein was prepared by affinity chromatography using glutathione Sepharose 4B. The purified rSj22.6 could be cleaved easily from the fusion protein with Thrombin. 17 and 12 mice immunized with rSj22.6 and Sj22.6/Sj26 GST separately were each challenged with 40 +/- 1 S. japonicum cercariae. RESULTS: In BALB/c mice, the rSj22.6 and Sj22.6/Sj26 GST could induce 32.1 (P < 0.005) and 34.9% (P < 0.02) worm reduction, respectively, as well as 28.4% (P < 0.02) and 45.1% (P < 0.005) total egg reduction, respectively. CONCLUSION: Bpth rSj22.6 and Sj22.6/Sj26 GST fusion protein are partially effective against S. japonicum.

[Studies on immunoprotection in mice after immunization with Schistosoma japonicum 22.6 kDa recombinant protein] Publishing Authors By Initials

C Su,L Ma,R Wang,X Hu,S Chen,L Shao,H Wu,L Shen,Z Zhang,G Wu,

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[Studies on immunoprotection in mice after immunization with Schistosoma japonicum 22.6 kDa recombinant protein] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing

VOLUME: 17

Page Numbers: 288-91

Journal Abbreviation: Zhongguo Ji Sheng Chong Xue Yu

ISSN: 1000-7423

DAY: 4

MONTH: 02

YEAR: 1999

[Studies on immunoprotection in mice after immunization with Schistosoma japonicum 22.6 kDa recombinant protein] Information

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LANGUAGE: chi

NlmUniqueID: 8709992

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Grant and Affiliation Information for [Studies on immunoprotection in mice after immunization with Schistosoma japonicum 22.6 kDa recombinant protein]

AFFILIATION: Department of Parasitology, Nanjing Medical University, Nanjing 210029.

Country: China

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MEDLINETA: Zhongguo Ji Sheng Chong Xue Yu

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