Studies of WT1 gene expression in leukemia patients.

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Studies of WT1 gene expression in leukemia patients. Abstract Text:

Zhongxia Huang,Bai Xiao,Shilun Chen,Shulan Li,Yingmei Liu,Jingzhong Liu,

OBJECTIVE: To explore the expression of WT1 gene in leukemia patients and its clinical implications. METHODS: Expression of WT1 mRNA was detected in two leukemia cell lines (K562 and HL-60), 49 acute leukemia (AL) patients, 33 chronic myeloid leukemia (CML) patients and 25 healthy subjects by reverse trans-criptase-nested polymerase chain reaction (RT-Nested PCR). RESULTS: WT1 gene was expressed in all subtype of AL including K562 and HL-60 cell lines, 21/29 newly diagnosed and relapsed AL patients, 1/20 complete remission (CR) AL patients, 15/18 CML blastic crisis patients, 1/5 CML patients in accelerated phase, and 1/10 CML patients in chronic phase. WT1 gene was undetectable in 25 healthy subjects. The expression level of WT1 gene was related to the prognosis of AL, patients with relative level >/= 1.0 had lower CR rates and disease-free survival. For CML patients, WT1 gene expression was associated with the clinical phase, it increased with disease progressed. CONCLUSION: WT1 gene expression is associated with pathogenesis of leukemia. It is a prognostic factor and a marker for the detection of minimal residual disease in AL and may used as an indicator for diagnosing CML blastic crisis.

Studies of WT1 gene expression in leukemia patients. Publishing Authors By Initials

Z Huang,B Xiao,S Chen,S Li,Y Liu,J Liu,

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Studies of WT1 gene expression in leukemia patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 23

Page Numbers: 367-9

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 4

MONTH: Jul

YEAR: 2002

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LANGUAGE: eng

NlmUniqueID: 8212398

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AFFILIATION: Chaoyang Hospital of Capital Medical University, Beijing 100020, China.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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