Structures and biological activities of peptidoglycans of Listeria monocytogenes and Propionibacterium acnes.

Structures and biological activities of peptidoglycans of Listeria monocytogenes and Propionibacterium acnes. Research Abstract Details 

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Structures and biological activities of peptidoglycans of Listeria monocytogenes and Propionibacterium acnes. Abstract Text:

K Kamisango,I Saiki,Y Tanio,H Okumura,Y Araki,I Sekikawa,I Azuma,Y Yamamura,

The cell-wall skeletons of Listeria monocytogenes strain EGD and Propionibacterium acnes strain C7, which have the ability to induce macrophage activation, were analyzed, and the structures of the peptidoglycans were investigated. The analytical data indicate that both peptidoglycans have glucosamine residues with free amino groups, which are responsible for the resistance to lysozyme. Possible structures of these peptidoglycans were deduced from the composition and the results of determination of N- and C-terminal amino acids, together with the characterization of fragments obtained by enzymatic treatment and partial acid hydrolysis of both peptidoglycans. The results suggested that the peptidoglycan of L. monocytogenes contains a cross-linkage region of peptide chains with meso-diaminopimelic acid and D-alanine, which belongs to the A1 gamma type (Schleifer, K.H. & Kandler, O. (1972) Bacteriol. Rev. 36, 407-477), whereas the peptidoglycan of P. acnes contains a cross-linkage region of peptide chains with L,L-diaminopimelic acid and D-alanine, in which two glycine residues combine with amino and carboxyl groups of two L,L-diaminopimelic acid residues. The latter type should be classified as a new type. These cell-wall skeletons and peptidoglycans were shown to have immunoadjuvant activity on the induction of delayed-type hypersensitivity and suppressive activity on the growth of 3-methylcholanthrene-induced fibrosarcoma in BALB/c mice, and the peptidoglycans were shown to be an immunological-active principle of these cell-wall skeletons.

Structures and biological activities of peptidoglycans of Listeria monocytogenes and Propionibacterium acnes. Publishing Authors By Initials

K Kamisango,I Saiki,Y Tanio,H Okumura,Y Araki,I Sekikawa,I Azuma,Y Yamamura,

For similar biological phenomena, cell phenomena, and immunity: immunity: antibody specificity: species specificity research abstracts see: biological phenomena, cell phenomena, and immunity: immunity: antibody specificity: species specificity research

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Structures and biological activities of peptidoglycans of Listeria monocytogenes and Propionibacterium acnes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 92

Page Numbers: 23-33

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jul

YEAR: 1982

Structures and biological activities of peptidoglycans of Listeria monocytogenes and Propionibacterium acnes. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Structures and biological activities of peptidoglycans of Listeria monocytogenes and Propionibacterium acnes. Keywords Mesh Terms:

KEYWORDS: Species Specificity

MESH TERMS: analysis

Chemical & Substance for Abstract: Structures and biological activities of peptidoglycans of Listeria monocytogenes and Propionibacterium acnes. Information

Substance Name: Peptidoglycan

Registry Number: 0

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Country: JAPAN

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MEDLINETA: J Biochem

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