Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Research Abstract Details 

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Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Abstract Text:

A Arockia Jeyaprakash,Ulf R Klein,Doris Lindner,Judith Ebert,Erich A Nigg,Elena Conti,A Arockia Jeyaprakash,Ulf R Klein,Doris Lindner,Judith Ebert,Erich A Nigg,Elena Conti,

The chromosomal passenger complex (CPC) is a key regulator of chromosome segregation and cytokinesis. CPC functions are connected to its localization. The complex first localizes to centromeres and later associates with the central spindle and midbody. Survivin, Borealin, and INCENP are the three components of the CPC that regulate the activity and localization of its enzymatic component, the kinase Aurora B. We determined the 1.4 A resolution crystal structure of the regulatory core of the CPC, revealing that Borealin and INCENP associate with the helical domain of Survivin to form a tight three-helical bundle. We used siRNA rescue experiments with structure-based mutants to explore the requirements for CPC localization. We show that the intertwined structural interactions of the core components lead to functional interdependence. Association of the core "passenger" proteins creates a single structural unit, whose composite molecular surface presents conserved residues essential for central spindle and midbody localization.

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Publishing Authors By Initials

AA Jeyaprakash,UR Klein,D Lindner,J Ebert,EA Nigg,E Conti,AA Jeyaprakash,UR Klein,D Lindner,J Ebert,EA Nigg,E Conti,

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Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell

VOLUME: 131

Page Numbers: 271-85

Journal Abbreviation: Cell

ISSN: 0092-8674

DAY: 19

MONTH: Oct

YEAR: 2007

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Information

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LANGUAGE: eng

NlmUniqueID: 413066

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Grant and Affiliation Information for Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.

AFFILIATION: Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.

Country: United States

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MEDLINETA: Cell

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