Structure and function of type I copper in multicopper oxidases.

Structure and function of type I copper in multicopper oxidases. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Structure and function of type I copper in multicopper oxidases. Abstract Text:

T Sakurai,K Kataoka,T Sakurai,K Kataoka,

The type I copper center in multicopper oxidases is constructed from 1Cys2His and weakly coordinating 1Met or the non-coordinating 1Phe/1Leu, and it exhibits spectral properties and an alkaline transition similar to those of the blue copper center in blue copper proteins. Since the type I copper center in multicopper oxidases is deeply buried inside the protein molecule, electron transfers to and from type I copper are performed through specific pathways: the hydrogen bond between an amino acid located at the substrate binding site and a His residue coordinating type I copper, and the His-Cys-His sequence connecting the type I copper center and the trinuclear copper center comprised of a type II copper and a pair of type III coppers. The intramolecular electron transfer rates can be tuned by mutating the fourth ligand of type I copper. Further, mutation at the Cys ligand gives a vacant type I copper center and traps the reaction intermediate during the four-electron reduction of dioxygen.

Structure and function of type I copper in multicopper oxidases. Publishing Authors By Initials

T Sakurai,K Kataoka,T Sakurai,K Kataoka,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Structure and function of type I copper in multicopper oxidases. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cellular and molecular life sciences : CMLS

VOLUME: 64

Page Numbers: 2642-56

Journal Abbreviation: Cell. Mol. Life Sci.

ISSN: 1420-682X

DAY: 30

MONTH: Oct

YEAR: 2007

Structure and function of type I copper in multicopper oxidases. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9705402

Structure and function of type I copper in multicopper oxidases. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Structure and function of type I copper in multicopper oxidases. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Structure and function of type I copper in multicopper oxidases.

AFFILIATION: Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa, 920-1192, Japan. ts0513@kenroku.kanazawa-u.ac.jp

Country: Switzerland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Cell Mol Life Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Structure and function of type I copper in multicopper oxidases Related Publications

• A histochemical study on glycoconjugates in epithelial cells in the distal colonic mucosa of adult and developing mice.
• AUREOCHROME, a photoreceptor required for photomorphogenesis in stramenopiles.
• Adverse Effect of Cyclosporin A on Barrier Functions of Cerebral Microvascular Endothelial Cells After Hypoxia-reoxygenation Damage In Vitro.
• Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles.
• Carbocyclization Reaction of omega-Iodo- and 1,omega-Diiodo-1-alkynes without the Loss of Iodine Atoms through a Carbenoid-Chain Process.
• Complement activation plays a key role in antibody-induced infusion toxicity in monkeys and rats.
• Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester.
• Cytotoxicity of Fas ligand against lymphoma cells with radiation-induced Fas antigen.
• Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1.
• Differential Regulation of Ecdysteroidogenic P450 Gene Expression in the Silkworm, Bombyx mori.
• Effect of organic anions on the photoreaction of photoactive yellow protein.
• Gene delivery with biocompatible cationic polymer: Pharmacogenomic analysis on cell bioactivity.
• Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells.
• MafA stability in pancreatic beta cells is regulated by glucose and is dependent on its constitutive phosphorylation at multiple sites by glycogen synthase kinase 3.
• Main-duct intraductal papillary mucinous adenoma of the pancreas with a large mural nodule.
• Multiple mechanisms and functions of maf transcription factors in the regulation of tissue-specific genes.
• PEGylated polyplex micelles from triblock catiomers with spatially ordered layering of condensed pDNA and buffering units for enhanced intracellular gene delivery.
• Phospholipase cepsilon Guanine nucleotide exchange factor activity and activation of rap1.
• Ras and Rap1 Activation of PLCvarepsilon Lipase Activity.
• Roles and Regulation of Transcription Factor MafA in Islet beta-cells.
• Roles of Kunitz domains in the anti-invasive effect of hepatocyte growth factor activator inhibitor type 1 in human glioblastoma cells.
• Roles of insulin-like growth factor binding protein-2 (IGFBP-2) in glioblastoma.
• Selective serotonin reuptake inhibitors fluvoxamine and paroxetine restore forced exercise-induced temperature dysregulation in ovariectomized mice.
• Structure and function of type I copper in multicopper oxidases.
• Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pKa directed to enhance intracellular gene silencing.
• Surgical repair for entire inferior vena cava occlusion in budd-Chiari syndrome.
• Unusual segmental stricture of the lower common bile duct mimicking bile duct cancer.
• [Pharmaceutical support at cardiovascular and cardiovascular surgery ward]
• [Type 1 allergy to formaldehyde in root canal sealant after dental treatment: two case reports and review of the literature]
• gamma-Tubulin-like molecules in the mouse duodenal epithelium.