Structure and expression of carp mitogen-activated protein kinases homologous to mammalian JNK/SAPK.

Structure and expression of carp mitogen-activated protein kinases homologous to mammalian JNK/SAPK. Research Abstract Details 

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Structure and expression of carp mitogen-activated protein kinases homologous to mammalian JNK/SAPK. Abstract Text:

H Hashimoto,Y Matsuo,Y Yokoyama,H Toyohara,M Sakaguchi,

Two distinct stress-activated protein kinase (JNKa and b) cDNAs were isolated from a carp ovary cDNA library. These cDNAs contained a full-length open reading frame encoding 427 amino acid residues with a predicted mass of 48.6 kDa. The deduced amino acid sequences of JNKa and b were 95.8% identical, with 18 residues replaced, and showed a high degree of sequence similarity to mammalian JNK/SAPK subgroup including the common dual phosphorylation motif of TPY. By Northern blot analysis, the carp JNKs were found to be abundant in the brain and ovary. Detailed study by RT-PCR assay revealed ubiquitous expression of JNKb, although expression of JNKa was specific to the brain and ovary. The high level expression of both JNKa and b in the ovary implies that JNKs play an important role in egg maturation or ectogenetic early development.

Structure and expression of carp mitogen-activated protein kinases homologous to mammalian JNK/SAPK. Publishing Authors By Initials

H Hashimoto,Y Matsuo,Y Yokoyama,H Toyohara,M Sakaguchi,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, amino acid research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, amino acid research

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Structure and expression of carp mitogen-activated protein kinases homologous to mammalian JNK/SAPK. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 122

Page Numbers: 381-6

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Aug

YEAR: 1997

Structure and expression of carp mitogen-activated protein kinases homologous to mammalian JNK/SAPK. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Structure and expression of carp mitogen-activated protein kinases homologous to mammalian JNK/SAPK. Keywords Mesh Terms:

KEYWORDS: Sequence Homology, Amino Acid

MESH TERMS: analysis

Chemical & Substance for Abstract: Structure and expression of carp mitogen-activated protein kinases homologous to mammalian JNK/SAPK. Information

Substance Name: Calcium-Calmodulin-Dependent Protein Kin

Registry Number: EC 2.7.11.17

Grant and Affiliation Information for Structure and expression of carp mitogen-activated protein kinases homologous to mammalian JNK/SAPK.

AFFILIATION: Advanced Course of Applied Biosciences, Graduate School of Agriculture, Kyoto University.

Country: JAPAN

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MEDLINETA: J Biochem

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ACCESSION NUMBER: D83273

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