Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation.

Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation. Research Abstract Details 

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Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation. Abstract Text:

Huchen Zhou,De-an Wang,Laura Baldini,Eileen Ennis,Rishi Jain,Adam Carie, Sebti,Andrew D Hamilton,

Platelet-derived growth factor (PDGF) and its receptor PDGFR are required for tumor growth and angiogenesis, so disruption of the PDGF-PDGFR interaction should lead to starvation of tumors and reduction of tumor growth. Potent PDGF antagonists have been discovered through the synthesis of a series of calix[4]arene-based compounds that are designed to bind to the three-loop region of PDGF. The effect of lower-rim alkylation, linker and number of interacting head groups on the calix[4]arene scaffold on PDGF affinity and cellular activity has been investigated.

Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation. Publishing Authors By Initials

H Zhou,DA Wang,L Baldini,E Ennis,R Jain,A Carie,SM Sebti,AD Hamilton,

For similar xenograft model antitumor assays research abstracts see: xenograft model antitumor assays research

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Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Organic & biomolecular chemistry

VOLUME: 4

Page Numbers: 2376-86

Journal Abbreviation: Org. Biomol. Chem.

ISSN: 1477-0520

DAY: 10

MONTH: 05

YEAR: 2006

Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101154995

Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation. Keywords Mesh Terms:

KEYWORDS: Xenograft Model Antitumor Assays

MESH TERMS: metabolism

Chemical & Substance for Abstract: Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation. Information

Substance Name: Receptors, Platelet-Derived Growth Facto

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation.

AFFILIATION: Department of Chemistry, Yale University, New Haven, CT 06520, USA.

Country: England

AGENCY: United States NIGMS

GRANT: GM 35208

ACRONYM: GM

MEDLINETA: Org Biomol Chem

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