Structure-activity Relationships of Neoechinulin A Analogues with Cytoprotection against Peroxynitrite-induced PC12 Cell Death.

Structure-activity Relationships of Neoechinulin A Analogues with Cytoprotection against Peroxynitrite-induced PC12 Cell Death. Research Abstract Details 

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Structure-activity Relationships of Neoechinulin A Analogues with Cytoprotection against Peroxynitrite-induced PC12 Cell Death. Abstract Text:

Kuniaki Kimoto,Toshiaki Aoki,Yasushi Shibata,Shinji Kamisuki,Fumio Sugawara,Kouji Kuramochi,Atsuo Nakazaki,Susumu Kobayashi,Kenji Kuroiwa,Nobuo Watanabe,Takao Arai,Kuniaki Kimoto,Toshiaki Aoki,Yasushi Shibata,Shinji Kamisuki,Fumio Sugawara,Kouji Kuramochi,Atsuo Nakazaki,Susumu Kobayashi,Kenji Kuroiwa,Nobuo Watanabe,Takao Arai,Kuniaki Kimoto,Toshiaki Aoki,Yasushi Shibata,Shinji Kamisuki,Fumio Sugawara,Kouji Kuramochi,Atsuo Nakazaki,Susumu Kobayashi,Kenji Kuroiwa,Nobuo Watanabe,Takao Arai,

Neoechinulin A, an alkaloid from Eurotium rubrum Hiji025, protected neuronal PC12 cells against cell death induced by peroxynitrite derived from SIN-1 (3-(4-morpholinyl)sydnonimine hydrochloride). In this study, we investigated the structure-activity relationships of neoechinulin A and a set of its analogues by using assays to measure anti-nitration and antioxidant activities and cytoprotection against SIN-1-induced PC12 cell death. The presence of the diketopiperazine ring was essential for both the antioxidant and anti-nitration activities of neoechinulin A derivatives. Nevertheless, a derivative lacking the diketopiperazine ring could still protect PC12 cells against SIN-1 cytotoxicity. An acyclic analogue completely lost the cytoprotective effect while retaining its antioxidant/anti-nitration activities. Pre-incubation of the cells with neoechinulin A for at least 12 hours was essential for the cells to gain SIN-1 resistance. These results suggest that neoechinulin A endows the cells with cytoprotection through a biological effect different from the apparent antioxidant/anti-nitration activities.

Structure-activity Relationships of Neoechinulin A Analogues with Cytoprotection against Peroxynitrite-induced PC12 Cell Death. Publishing Authors By Initials

K Kimoto,T Aoki,Y Shibata,S Kamisuki,F Sugawara,K Kuramochi,A Nakazaki,S Kobayashi,K Kuroiwa,N Watanabe,T Arai,K Kimoto,T Aoki,Y Shibata,S Kamisuki,F Sugawara,K Kuramochi,A Nakazaki,S Kobayashi,K Kuroiwa,N Watanabe,T Arai,K Kimoto,T Aoki,Y Shibata,S Kamisuki,F Sugawara,K Kuramochi,A Nakazaki,S Kobayashi,K Kuroiwa,N Watanabe,T Arai,

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Structure-activity Relationships of Neoechinulin A Analogues with Cytoprotection against Peroxynitrite-induced PC12 Cell Death. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of antibiotics

VOLUME: 60

Page Numbers: 614-21

Journal Abbreviation: J. Antibiot.

ISSN: 0021-8820

DAY: 29

MONTH: Oct

YEAR: 2007

Structure-activity Relationships of Neoechinulin A Analogues with Cytoprotection against Peroxynitrite-induced PC12 Cell Death. Information

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LANGUAGE: eng

NlmUniqueID: 151115

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Grant and Affiliation Information for Structure-activity Relationships of Neoechinulin A Analogues with Cytoprotection against Peroxynitrite-induced PC12 Cell Death.

AFFILIATION: Department of Applied Biological Science, Faculty of Science and Technology.

Country: Japan

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MEDLINETA: J Antibiot (Tokyo)

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