Structure-activity relationships of 6-hydroxy-7-methoxychroman-2-carboxylic acid N-(substituted)phenylamides as inhibitors of nuclear factor-kappaB activation.

Structure-activity relationships of 6-hydroxy-7-methoxychroman-2-carboxylic acid N-(substituted)phenylamides as inhibitors of nuclear factor-kappaB activation. Research Abstract Details 

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Structure-activity relationships of 6-hydroxy-7-methoxychroman-2-carboxylic acid N-(substituted)phenylamides as inhibitors of nuclear factor-kappaB activation. Abstract Text:

Jae-Hwan Kwak,Byung Hak Kim,Jae-Kyung Jung,Youngsoo Kim,Jungsook Cho,Heesoon Lee,Jae-Hwan Kwak,Byung Hak Kim,Jae-Kyung Jung,Youngsoo Kim,Jungsook Cho,Heesoon Lee,

A series of 6-hydroxy-7-methoxychroman-2-carboxylic acid N-substitutedphenylamides (2a-n) were synthesized and their ability to inhibit nuclear factor-kappaB activity was evaluated in lipopolysaccharide (LPS)-stimulated macrophage RAW 264.7 cells. While compounds bearing -OH, or -OCH3 substituents were inactive, compounds with -CH3, -CF3, or -Cl substituents were potent inhibitors (IC50: 6.0-60.2 microM). The most active compound, 2n, contained a 4-Cl substituent on the phenyl ring and was four times more potent than the compound KL-1156.

Structure-activity relationships of 6-hydroxy-7-methoxychroman-2-carboxylic acid N-(substituted)phenylamides as inhibitors of nuclear factor-kappaB activation. Publishing Authors By Initials

JH Kwak,BH Kim,JK Jung,Y Kim,J Cho,H Lee,JH Kwak,BH Kim,JK Jung,Y Kim,J Cho,H Lee,

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Structure-activity relationships of 6-hydroxy-7-methoxychroman-2-carboxylic acid N-(substituted)phenylamides as inhibitors of nuclear factor-kappaB activation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of pharmacal research

VOLUME: 30

Page Numbers: 1210-5

Journal Abbreviation: Arch. Pharm. Res.

ISSN: 0253-6269

DAY: 27

MONTH: Oct

YEAR: 2007

Structure-activity relationships of 6-hydroxy-7-methoxychroman-2-carboxylic acid N-(substituted)phenylamides as inhibitors of nuclear factor-kappaB activation. Information

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LANGUAGE: eng

NlmUniqueID: 8000036

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AFFILIATION: College of Pharmacy, Chungbuk National University, Cheongiu 361-763, Korea.

Country: Korea (South)

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MEDLINETA: Arch Pharm Res

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