Structure-activity relationship studies on quorum sensing ComX(RO-E-2) pheromone.

Structure-activity relationship studies on quorum sensing ComX(RO-E-2) pheromone. Research Abstract Details 

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Structure-activity relationship studies on quorum sensing ComX(RO-E-2) pheromone. Abstract Text:

Masahiro Okada,Hisao Yamaguchi,Isao Sato,Soo Jeong Cho,David Dubnau,Youji Sakagami,

The ComX pheromone is a posttranslationally modified oligopeptide that stimulates natural genetic competence in Bacillus subtilis. Various ComX(RO-E-2) analogs were synthesized and their biological activities were studied to investigate structure-activity relationships. These results showed that the minimal active unit was the tripeptide, [3-5]ComX(RO-E-2), and all residues except the modified tryptophan residue were replaceable by alanine without total loss of activity.

Structure-activity relationship studies on quorum sensing ComX(RO-E-2) pheromone. Publishing Authors By Initials

M Okada,H Yamaguchi,I Sato,SJ Cho,D Dubnau,Y Sakagami,

For similar amino acids, peptides, and proteins: amino acids: amino acids, cyclic: amino acids, aromatic: tryptophan research abstracts see: amino acids, peptides, and proteins: amino acids: amino acids, cyclic: amino acids, aromatic: tryptophan research

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Structure-activity relationship studies on quorum sensing ComX(RO-E-2) pheromone. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 1705-7

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 23

MONTH: 12

YEAR: 2006

Structure-activity relationship studies on quorum sensing ComX(RO-E-2) pheromone. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

Structure-activity relationship studies on quorum sensing ComX(RO-E-2) pheromone. Keywords Mesh Terms:

KEYWORDS: Tryptophan

MESH TERMS: chemistry

Chemical & Substance for Abstract: Structure-activity relationship studies on quorum sensing ComX(RO-E-2) pheromone. Information

Substance Name: Tryptophan

Registry Number: 73-22-3

Grant and Affiliation Information for Structure-activity relationship studies on quorum sensing ComX(RO-E-2) pheromone.

AFFILIATION: Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan. okada-org@mail.tains.tohoku.ac,jp

Country: England

AGENCY: United States NIGMS

GRANT: GM 57720

ACRONYM: GM

MEDLINETA: Bioorg Med Chem Lett

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