Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists.

Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists. Research Abstract Details 

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Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists. Abstract Text:

Vijay K Gore,Vu V Ma,Rami Tamir,Narender R Gavva,James J S Treanor,Mark H Norman,Vijay K Gore,Vu V Ma,Rami Tamir,Narender R Gavva,James J S Treanor,Mark H Norman,

A novel series of 4,5-biarylimidazoles as TRPV1 antagonists were designed based on the previously reported 4,6-disubstituted benzimidazole series. The analogs were evaluated for their ability to block capsaicin- or acid-induced calcium influx in TRPV1-expressing CHO cells. These studies led to the identification of a highly potent and orally bioavailable TRPV1 antagonist, imidazole 33.

Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists. Publishing Authors By Initials

VK Gore,VV Ma,R Tamir,NR Gavva,JJ Treanor,MH Norman,VK Gore,VV Ma,R Tamir,NR Gavva,JJ Treanor,MH Norman,

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Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 5825-30

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 25

MONTH: 08

YEAR: 2007

Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

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Grant and Affiliation Information for Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists.

AFFILIATION: Chemistry Research & Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. vgore@amgen.com

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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