Structural polymorphism of I-E subregion antigens determined by a gene in the H-2K to I-B genetic interval.

Structural polymorphism of I-E subregion antigens determined by a gene in the H-2K to I-B genetic interval. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Structural polymorphism of I-E subregion antigens determined by a gene in the H-2K to I-B genetic interval. Abstract Text:

J Silver,W A Russell,

THE generation of immune responses in mice is influenced by Ir genes located in the I region of the major histocompatibility complex (MHC)(1). In some instances maximum responses require complementation by two genes, one in the I-A or I-B and the other in the I-E or I-C subregion(2,3). The effects of these genes are thought to be mediated by Ia alloantigens, which are cell surface molecules whose expression is controlled by the I region(4). This is based on the observations that anti-Ia sera inhibit in vitro immune responses(5,6), and soluble factors that enhance in vitro immune responses express Ia alloantigenic determinants(7,9). Jones et al.(10), using two-dimensional gel electrophoresis, observed that the expression of I-E subregion antigens is controlled by two genes, one in the I-A subregion, the other in the I-E subregion, and that the polymorphism of these antigens is influenced by an I-A subregion gene. As an explanation, the authors proposed that only one of the two polypeptide chains present in I-E immunoprecipitates is an I-E subregion product, the second being a product of the I-A subregion. Antisera obtained by cross-immunisation of I-E subregion-disparate strains of mice immunoprecipitates a molecular complex consisting of two chains, designated alpha and beta, with molecular weights of 32,000 and 29,000 respectively(11-14). Previous studies suggested that I-E antigens isolated from B10.A(5R) and B10.D2 mice had identical alpha-chains but different (beta)-chains(15). However, as these mice differed at multiple genetic regions, it was not possible to show which I subregion(s) determined the polymorphism of the E(beta) chain. Therefore, we investigated the effects of the I-A subregion on the polymorphism of I-E subregion antigens. We have now shown by peptide mapping that the I-E subregion polymorphism which Jones et al. found to be controlled by the I-A subregion probably reflects structural polymorphism of beta-chains controlled by an I-A subregion gene.

Structural polymorphism of I-E subregion antigens determined by a gene in the H-2K to I-B genetic interval. Publishing Authors By Initials

J Silver,WA Russell,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Structural polymorphism of I-E subregion antigens determined by a gene in the H-2K to I-B genetic interval. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nature

VOLUME: 279

Page Numbers: 437-9

Journal Abbreviation: Nature

ISSN: 0028-0836

DAY: 31

MONTH: May

YEAR: 1979

Structural polymorphism of I-E subregion antigens determined by a gene in the H-2K to I-B genetic interval. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 410462

Structural polymorphism of I-E subregion antigens determined by a gene in the H-2K to I-B genetic interval. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Structural polymorphism of I-E subregion antigens determined by a gene in the H-2K to I-B genetic interval. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Structural polymorphism of I-E subregion antigens determined by a gene in the H-2K to I-B genetic interval.

AFFILIATION:

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Nature

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Structural polymorphism of I-E subregion antigens determined by a gene in the H-2K to I-B genetic interval Related Publications

• Autonomic dysfunction in obstructive sleep apnea is associated with impaired glucose regulation.
• Binding isotherms by continuous-flow dynamic dialysis.
• Columnar cell variant of papillary thyroid carcinoma.
• Commentary to 'Comorbidity in Finnish migraine families'.
• Comparison of the genetic effects of equimolar doses of ENU and MNU: while the chemicals differ dramatically in their mutagenicity in stem-cell spermatogonia, both elicit very high mutation rates in differentiating spermatogonia.
• Dynamic posttranscriptional regulation of epsilon-globin gene expression in vivo.
• Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.
• Evidence-based fertility treatment: what do we mean?
• Foamy-virus-mediated gene transfer to canine repopulating cells.
• In vivo quantitation of intratumoral radioisotope uptake using micro-single photon emission computed tomography/computed tomography.
• Infected cell carriers: a new strategy for systemic delivery of oncolytic measles viruses in cancer virotherapy.
• Letter to the editor.
• Magnesium deficiency in patients on home enteral nutrition.
• Metabotropic glutamate receptor 3 protects neurons from glucose-induced oxidative injury by increasing intracellular glutathione concentration.
• Morphine-stimulated nitric oxide release in rabbit aqueous humor.
• Mutation of beta-glucosidase 2 causes glycolipid storage disease and impaired male fertility.
• Nonspecific binding to structured RNA and preferential unwinding of an exposed helix by the CYT-19 protein, a DEAD-box RNA chaperone.
• Novel transparent nano- to micro-heterogeneous substrates for in-situ cell migration study.
• Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin.
• Ovine bronchial-derived relaxing factor: changes with development and hyperoxic ventilation.
• Probing the mechanisms of DEAD-box proteins as general RNA chaperones: the C-terminal domain of CYT-19 mediates general recognition of RNA.
• Relationship of seminal vesicle size and measures of libido in yearling beef bulls.
• Removal of Ocular Artifacts from EEG: A Comparison of Adaptive Filtering Method and Regression Method Using Simulated Data.
• Small animal absorbed radiation dose from serial micro-computed tomography imaging.
• Solitary intramedullary plasmacytoma of the skull base mimicking aggressive meningioma.
• Spring-loaded heptad repeat residues regulate the expression and activation of paramyxovirus fusion protein.
• Structural polymorphism of I-E subregion antigens determined by a gene in the H-2K to I-B genetic interval.
• T-cell depletion eliminates the development of cardiac allograft vasculopathy in mice rendered tolerant by the induction of mixed chimerism.
• The prevalence and characteristics of migraine in twins from the general population.
• Who is publishing in Theriogenology and on what subjects?