Structural magnetic resonance imaging in patients with first-episode schizophrenia, psychotic and severe non-psychotic depression and healthy controls. Results of the schizophrenia and affective psychoses (SAP) project.

Structural magnetic resonance imaging in patients with first-episode schizophrenia, psychotic and severe non-psychotic depression and healthy controls. Results of the schizophrenia and affective psychoses (SAP) project. Research Abstract Details 

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Structural magnetic resonance imaging in patients with first-episode schizophrenia, psychotic and severe non-psychotic depression and healthy controls. Results of the schizophrenia and affective psychoses (SAP) project. Abstract Text:

R K R Salokangas,T Cannon,T Van Erp,T Ilonen,T Taiminen,H Karlsson,H Lauerma,K M Leinonen,E Wallenius,A Kaljonen,E Syvälahti,H Vilkman,A Alanen,J Hietala,

BACKGROUND: Structural brain abnormalities are prevalent in patients with schizophrenia and affective disorders. AIMS: To study how regional brain volumes and their ratios differ between patients with schizophrenia, psychotic depression, severe non-psychotic depression and healthy controls. METHOD: Magnetic resonance imaging scans of the brain on first-episode patients and on healthy controls. RESULTS: Patients with schizophrenia had a smaller left frontal grey matter volume than the other three groups. Patients with psychotic depression had larger ventricular and posterior sulcal cerebrospinal fluid (CSF) volumes than controls. Patients with depression had larger white matter volumes than the other patients. CONCLUSIONS: Left frontal lobe, especially its grey matter volume, seems to be specifically reduced in first-episode schizophrenia. Enlarged cerebral ventricles and sulcal CSF volumes are prevalent in psychotic depression. Preserved or expanded white matter is typical of non-psychotic depression.

Structural magnetic resonance imaging in patients with first-episode schizophrenia, psychotic and severe non-psychotic depression and healthy controls. Results of the schizophrenia and affective psychoses (SAP) project. Publishing Authors By Initials

RK Salokangas,T Cannon,T Van Erp,T Ilonen,T Taiminen,H Karlsson,H Lauerma,KM Leinonen,E Wallenius,A Kaljonen,E Syvälahti,H Vilkman,A Alanen,J Hietala,

For similar mental disorders: schizophrenia and disorders with psychotic features: schizophrenia research abstracts see: mental disorders: schizophrenia and disorders with psychotic features: schizophrenia research

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Structural magnetic resonance imaging in patients with first-episode schizophrenia, psychotic and severe non-psychotic depression and healthy controls. Results of the schizophrenia and affective psychoses (SAP) project. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The British journal of psychiatry. Supplement

VOLUME: 43

Page Numbers: s58-65

Journal Abbreviation:

ISSN: 0960-5371

DAY: 22

MONTH: Sep

YEAR: 2002

Structural magnetic resonance imaging in patients with first-episode schizophrenia, psychotic and severe non-psychotic depression and healthy controls. Results of the schizophrenia and affective psychoses (SAP) project. Information

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LANGUAGE: eng

NlmUniqueID: 9001294

Structural magnetic resonance imaging in patients with first-episode schizophrenia, psychotic and severe non-psychotic depression and healthy controls. Results of the schizophrenia and affective psychoses (SAP) project. Keywords Mesh Terms:

KEYWORDS: Schizophrenia

MESH TERMS: diagnosis

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Grant and Affiliation Information for Structural magnetic resonance imaging in patients with first-episode schizophrenia, psychotic and severe non-psychotic depression and healthy controls. Results of the schizophrenia and affective psychoses (SAP) project.

AFFILIATION: Department of Psychiatry, University of Turku, Turku University Central Hospital and Turku Psychiatric Clinic, Finland. Raimo.K.R.Salokangas@tyks.fi

Country: England

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MEDLINETA: Br J Psychiatry Suppl

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