Structural insights on the translation initiation complex: ghosts of a universal initiation complex.

Structural insights on the translation initiation complex: ghosts of a universal initiation complex. Research Abstract Details 

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Structural insights on the translation initiation complex: ghosts of a universal initiation complex. Abstract Text:

Gregory S Allen,Joachim Frank,

All living organisms utilize ribosomes to translate messenger RNA into proteins. Initiation of translation, the process of bringing together mRNA, initiator transfer RNA, and the ribosome, is therefore of critical importance to all living things. Two protein factors, IF1 (a/eIF1A) and IF2 (a/eIF5B), are conserved among all three kingdoms of life and have been called universal initiation factors (Roll-Mecak et al., 2001). Recent X-ray, NMR and cryo-EM structures of the universal factors, alone and in complex with eubacterial ribosomes, point to the structural homology among the initiation factors and initiation complexes. Taken together with genomic and functional evidence, the structural studies allow us to predict some features of eukaryotic and archaeal initiation complexes. Although initiation of translation in eukaryotes and archaea requires more initiation factors than in eubacteria we propose the existence of a common denominator initiation complex with structural and functional homology across all kingdoms of life.

Structural insights on the translation initiation complex: ghosts of a universal initiation complex. Publishing Authors By Initials

GS Allen,J Frank,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: molecular conformation: protein conformation research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: molecular conformation: protein conformation research

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Structural insights on the translation initiation complex: ghosts of a universal initiation complex. Journal Published:

PUBLICATION TYPE: Review

Journal: Molecular microbiology

VOLUME: 63

Page Numbers: 941-50

Journal Abbreviation: Mol. Microbiol.

ISSN: 0950-382X

DAY: 3

MONTH: Feb

YEAR: 2007

Structural insights on the translation initiation complex: ghosts of a universal initiation complex. Information

Number of References: 93

LANGUAGE: eng

NlmUniqueID: 8712028

Structural insights on the translation initiation complex: ghosts of a universal initiation complex. Keywords Mesh Terms:

KEYWORDS: Protein Conformation

MESH TERMS: metabolism

Chemical & Substance for Abstract: Structural insights on the translation initiation complex: ghosts of a universal initiation complex. Information

Substance Name: Prokaryotic Initiation Factor-2

Registry Number: 0

Grant and Affiliation Information for Structural insights on the translation initiation complex: ghosts of a universal initiation complex.

AFFILIATION: Howard Hughes Medical Institute, Health Research, Inc., Wadsworth Center, Empire State Plaza, Albany, NY 12201, USA.

Country: England

AGENCY: United States NIGMS

GRANT: R37 GM29169

ACRONYM: GM

MEDLINETA: Mol Microbiol

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