Structural insight into OprD substrate specificity.

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Structural insight into OprD substrate specificity. Abstract Text:

Shyamasri Biswas,Mohammad M Mohammad,Dimki R Patel,Liviu Movileanu,Bert van den Berg,

OprD proteins form a large family of substrate-specific outer-membrane channels in Gram-negative bacteria. We report here the X-ray crystal structure of OprD from Pseudomonas aeruginosa, which reveals a monomeric 18-stranded beta-barrel characterized by a very narrow pore constriction, with a positively charged basic ladder on one side and an electronegative pocket on the other side. The location of highly conserved residues in OprD suggests that the structure represents the general architecture of OprD channels.

Structural insight into OprD substrate specificity. Publishing Authors By Initials

S Biswas,MM Mohammad,DR Patel,L Movileanu,B van den Berg,

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Structural insight into OprD substrate specificity. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Nature structural & molecular biology

VOLUME: 14

Page Numbers: 1108-9

Journal Abbreviation: Nat. Struct. Mol. Biol.

ISSN: 1545-9985

DAY: 21

MONTH: 10

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 101186374

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AFFILIATION: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

Country: United States

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MEDLINETA: Nat Struct Mol Biol

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