Structural divergence among cannabinoids influences membrane dynamics: a 2H solid-state NMR analysis.

Structural divergence among cannabinoids influences membrane dynamics: a 2H solid-state NMR analysis. Research Abstract Details 

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Structural divergence among cannabinoids influences membrane dynamics: a 2H solid-state NMR analysis. Abstract Text:

Elvis K Tiburu,Caroline E Bass,Jochem O Struppe,Gary A Lorigan,Shalom Avraham,Hava Karsenty Avraham,

Cannabinoids are compounds that can modulate neuronal functions and immune responses via their activity at the CB(1) receptor. We used (2)H NMR order parameters and relaxation rate determination to delineate the behavior of magnetically aligned phospholipid bilayers in the presence of several structurally distinct cannabinoid ligands. THC (Delta(9)-Tetrahydrocannabinol) and WIN-55,212-2 were found to lower the phase transition temperature of the DMPC and to destabilize their acyl chains leading to a lower average S(CD) ( approximately 0.13), while methanandamide and CP-55,940 exhibited unusual properties within the lipid bilayer resulting in a greater average S(CD) ( approximately 0.14) at the top of the phospholipid upper chain. The CB(1) antagonist AM281 had average S(CD) values that were higher than the pure DMPC lipids, indicating a stabilization of the lipid bilayer. R(1Z) versus |S(CD)|(2) plots indicated that the membrane fluidity is increased in the presence of THC and WIN-55,212-2. The interaction of CP-55,940 with a variety of zwitterionic and charged membranes was also assessed. The unusual effect of CP-55,940 was present only in bicelles composed of DMPC. These studies strongly suggest that cannabinoid action on the membrane depends upon membrane composition as well as the structure of the cannabinoid ligands.

Structural divergence among cannabinoids influences membrane dynamics: a 2H solid-state NMR analysis. Publishing Authors By Initials

EK Tiburu,CE Bass,JO Struppe,GA Lorigan,S Avraham,HK Avraham,

For similar natural sciences: chemistry: chemistry, physical: phase transition research abstracts see: natural sciences: chemistry: chemistry, physical: phase transition research

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Structural divergence among cannabinoids influences membrane dynamics: a 2H solid-state NMR analysis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biochimica et biophysica acta

VOLUME: 1768

Page Numbers: 2049-59

Journal Abbreviation: Biochim. Biophys. Acta

ISSN: 0006-3002

DAY: 5

MONTH: 05

YEAR: 2007

Structural divergence among cannabinoids influences membrane dynamics: a 2H solid-state NMR analysis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 217513

Structural divergence among cannabinoids influences membrane dynamics: a 2H solid-state NMR analysis. Keywords Mesh Terms:

KEYWORDS: Phase Transition

MESH TERMS: drug effects

Chemical & Substance for Abstract: Structural divergence among cannabinoids influences membrane dynamics: a 2H solid-state NMR analysis. Information

Substance Name: Dimyristoylphosphatidylcholine

Registry Number: 13699-48-4

Grant and Affiliation Information for Structural divergence among cannabinoids influences membrane dynamics: a 2H solid-state NMR analysis.

AFFILIATION: Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA.

Country: Netherlands

AGENCY: United States NHLBI

GRANT: HL07917-06

ACRONYM: HL

MEDLINETA: Biochim Biophys Acta

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