Structural control of self-assembled nanofibers by artificial beta-sheet peptides composed of D- or L-isomer.

Structural control of self-assembled nanofibers by artificial beta-sheet peptides composed of D- or L-isomer. Research Abstract Details 

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Structural control of self-assembled nanofibers by artificial beta-sheet peptides composed of D- or L-isomer. Abstract Text:

Tomoyuki Koga,Miho Matsuoka,Nobuyuki Higashi,

A novel method for the control of peptide self-assembly has been developed by using synthetic triblock-type beta-sheet peptides composed of l- or d-amino acid, 1L and 1D, as building blocks. The peptides 1L and 1D self-assemble into beta-sheet nanofibers with left- and right-handed twists, respectively, under appropriate condition. On the other hand, the 1L/1D binary mixture was found to form only globular aggregates at the same condition. Thus, amyloid-like nanofiber formation and its nanostructure could be successfully regulated by the stereospecificity of the constituent peptide species.

Structural control of self-assembled nanofibers by artificial beta-sheet peptides composed of D- or L-isomer. Publishing Authors By Initials

T Koga,M Matsuoka,N Higashi,

For similar proteins: blood proteins: serum globulins: beta-globulins: beta 2-microglobulin research abstracts see: proteins: blood proteins: serum globulins: beta-globulins: beta 2-microglobulin research

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Structural control of self-assembled nanofibers by artificial beta-sheet peptides composed of D- or L-isomer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Chemical Society

VOLUME: 127

Page Numbers: 17596-7

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 21

MONTH: Dec

YEAR: 2005

Structural control of self-assembled nanofibers by artificial beta-sheet peptides composed of D- or L-isomer. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Structural control of self-assembled nanofibers by artificial beta-sheet peptides composed of D- or L-isomer. Keywords Mesh Terms:

KEYWORDS: beta 2-Microglobulin

MESH TERMS: chemistry

Chemical & Substance for Abstract: Structural control of self-assembled nanofibers by artificial beta-sheet peptides composed of D- or L-isomer. Information

Substance Name: Leucine

Registry Number: 61-90-5

Grant and Affiliation Information for Structural control of self-assembled nanofibers by artificial beta-sheet peptides composed of D- or L-isomer.

AFFILIATION: Department of Molecular Science and Technology, Faculty of Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321, Japan.

Country: United States

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MEDLINETA: J Am Chem Soc

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