Structural basis for ligand recognition by integrins.

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Structural basis for ligand recognition by integrins. Abstract Text:

Junichi Takagi,Junichi Takagi,Junichi Takagi,

Integrins, the major cell surface receptors mediating cell-extracellular matrix (ECM) adhesion, are central to the basic physiology underlying all multicellular organisms. As the complexity of animal body architecture increased, integrins were forced to acquire recognition capabilities toward the wide variety of ECM ligands and cell surface counter-receptors that emerged during evolution. Structural determination of the integrin-ligand complexes for both I domain-containing and non-I domain-containing integrins revealed two fundamentally different types of integrin-binding surfaces. In addition, recent advances in the biochemical and pharmacological characterization of the integrin-ligand interactions are beginning to reveal how integrins achieve specific recognition of wide variety of ligands using a small binding cleft at the subunit interface common to all integrins.

Structural basis for ligand recognition by integrins. Publishing Authors By Initials

J Takagi,J Takagi,J Takagi,

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Structural basis for ligand recognition by integrins. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current opinion in cell biology

VOLUME: 19

Page Numbers: 557-64

Journal Abbreviation: Curr. Opin. Cell Biol.

ISSN: 0955-0674

DAY: 17

MONTH: 10

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 8913428

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AFFILIATION: Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

Country: United States

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MEDLINETA: Curr Opin Cell Biol

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