Structural Basis for EGF Receptor Inhibition by the Therapeutic Antibody IMC-11F8.

Structural Basis for EGF Receptor Inhibition by the Therapeutic Antibody IMC-11F8. Research Abstract Details 

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Structural Basis for EGF Receptor Inhibition by the Therapeutic Antibody IMC-11F8. Abstract Text:

Shiqing Li,Paul Kussie,Kathryn M Ferguson,

Therapeutic anticancer strategies that target and inactivate the epidermal growth factor receptor (EGFR) are under intense study in the clinic. Here we describe the mechanism of EGFR inhibition by an antibody drug IMC-11F8. IMC-11F8 is a fully human antibody that has similar antitumor potency as the chimeric cetuximab/Erbitux and might represent a safer therapeutic alternative. We report the X-ray crystal structure of the Fab fragment of IMC-11F8 (Fab11F8) in complex with the entire extracellular region and with isolated domain III of EGFR. We compare this to our previous study of the cetuximab/EGFR interaction. Fab11F8 interacts with a remarkably similar epitope, but through a completely different set of interactions. Both the similarities and differences in binding of these two antibodies have important implications for the development of inhibitors that could exploit this same mechanism of EGFR inhibition.

Structural Basis for EGF Receptor Inhibition by the Therapeutic Antibody IMC-11F8. Publishing Authors By Initials

S Li,P Kussie,KM Ferguson,

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Structural Basis for EGF Receptor Inhibition by the Therapeutic Antibody IMC-11F8. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Structure (London, England : 1993)

VOLUME: 16

Page Numbers: 216-27

Journal Abbreviation: Structure

ISSN: 0969-2126

DAY: 15

MONTH: Feb

YEAR: 2008

Structural Basis for EGF Receptor Inhibition by the Therapeutic Antibody IMC-11F8. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Structural Basis for EGF Receptor Inhibition by the Therapeutic Antibody IMC-11F8.

AFFILIATION: Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Country: United States

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MEDLINETA: Structure

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