Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle.

Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle. Research Abstract Details 

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Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle. Abstract Text:

Ilona A Barash,Marie-Louise Bang,Liby Mathew,Marion L Greaser,Ju Chen,Richard L Lieber,

The biological response of muscle to eccentric contractions (ECs) results in strengthening and protection from further injury. However, the cellular basis for this response remains unclear. Previous studies identified the muscle ankyrin repeat protein (MARP) family, consisting of cardiac ankyrin repeat protein (CARP), ankyrin repeat domain 2/ankyrin repeat protein with PEST and proline-rich region (Ankrd2/Arpp), and diabetes-associated ankyrin repeat protein (DARP), as rapidly and specifically upregulated in mice after a single bout of EC. To determine the role of these genes in skeletal muscle, a survey of skeletal muscle structural and functional characteristics was performed on mice lacking all three MARP family members (MKO). There was a slight trend toward MKO muscles having a slower fiber type distribution but no differences in muscle fiber size. Single MKO fibers were less stiff, tended to have longer resting sarcomere lengths, and expressed a longer isoform of titin than their wild-type counterparts, indicating that these proteins may play a role in the passive mechanical behavior of muscle. Finally, MKO mice showed a greater degree of torque loss after a bout of ECs compared with wild-type mice, although they recovered from the injury with the same or even improved time course. This recovery was associated with enhanced expression of the muscle regulatory genes MyoD and muscle LIM protein (MLP), suggesting that the MARP family may play both important structural and gene regulatory roles in skeletal muscle.

Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle. Publishing Authors By Initials

IA Barash,ML Bang,L Mathew,ML Greaser,J Chen,RL Lieber,

For similar biomechanics: torsion, mechanical: torque research abstracts see: biomechanics: torsion, mechanical: torque research

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Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: American journal of physiology. Cell physiology

VOLUME: 293

Page Numbers: C218-27

Journal Abbreviation: Am. J. Physiol., Cell Physiol.

ISSN: 0363-6143

DAY: 28

MONTH: 03

YEAR: 2007

Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901225

Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle. Keywords Mesh Terms:

KEYWORDS: Torque

MESH TERMS: metabolism

Chemical & Substance for Abstract: Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle. Information

Substance Name: Protein Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle.

AFFILIATION: Dept. of Orthopaedics, University of California, Department of Veterans Affairs Medical Center, San Diego, CA 92161, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: AR45039

ACRONYM: AR

MEDLINETA: Am J Physiol Cell Physiol

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