Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors.

Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Research Abstract Details 

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Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Abstract Text:

Nerve growth factor engages two structurally distinct transmembrane receptors, TrkA and p75, which have been proposed to create a "high-affinity" NGF binding site through formation of a ternary TrkA/NGF/p75 complex. To define a structural basis for the high-affinity site, we have determined the three-dimensional structure of a complete extracellular domain of TrkA complexed with NGF. The complex reveals a crab-shaped homodimeric TrkA structure, but a mechanism for p75 coordination is not obvious. We investigated the heterodimerization of membrane-bound TrkA and p75, on intact mammalian cells, using a beta-gal protein-protein interaction system. We find that NGF dimerizes TrkA and that p75 exists on the cell surface as a preformed oligomer that is not dissociated by NGF. We find no evidence for a direct TrkA/p75 interaction. We propose that TrkA and p75 likely communicate through convergence of downstream signaling pathways and/or shared adaptor molecules, rather than through direct extracellular interactions.

Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Publishing Authors By Initials

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuron

VOLUME: 53

Page Numbers: 25-38

Journal Abbreviation: Neuron

ISSN: 0896-6273

DAY: 4

MONTH: Jan

YEAR: 2007

Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8809320

Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Information

Substance Name: Receptor, trkA

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors.

AFFILIATION: Baxter Laboratory for Genetic Pharmacology, Department of Microbiology and Immunology, The Stem Cell Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

Country: United States

AGENCY: United States NICHD

GRANT: HD018179

ACRONYM: HD

MEDLINETA: Neuron

REFSOURCE: Neuron. 2007 Jan 4;53(1):1-4

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ACCESSION NUMBER: 2IFG

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