Strongly emissive individual DNA-encapsulated Ag nanoclusters as single-molecule fluorophores.

Strongly emissive individual DNA-encapsulated Ag nanoclusters as single-molecule fluorophores. Research Abstract Details 

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Strongly emissive individual DNA-encapsulated Ag nanoclusters as single-molecule fluorophores. Abstract Text:

Tom Vosch,Yasuko Antoku,Jung-Cheng Hsiang,Chris I Richards,Jose I Gonzalez,Robert M Dickson,

The water-soluble, near-IR-emitting DNA-encapsulated silver nanocluster presented herein exhibits extremely bright and photostable emission on the single-molecule and bulk levels. The photophysics have been elucidated by intensity-dependent correlation analysis and suggest a heavy atom effect of silver that rapidly depopulates an excited dark level before quenching by oxygen, thereby conferring great photostability, very high single-molecule emission rates, and essentially no blinking on experimentally relevant time scales (0.1 to >1,000 ms). Strong antibunching is observed from these biocompatible species, which emit >10(9) photons before photobleaching. The significant dark-state quantum yield even enables bunching from the emissive state to be observed as a dip in the autocorrelation curve with only a single detector as the dark state precludes emission from the emissive level. These species represent significant improvements over existing dyes, and the nonpower law blinking kinetics suggest that these very small species may be alternatives to much larger and strongly intermittent semiconductor quantum dots.

Strongly emissive individual DNA-encapsulated Ag nanoclusters as single-molecule fluorophores. Publishing Authors By Initials

T Vosch,Y Antoku,JC Hsiang,CI Richards,JI Gonzalez,RM Dickson,

For similar investigative techniques: chemistry, analytical: photometry: spectrophotometry: spectrophotometry, infrared research abstracts see: investigative techniques: chemistry, analytical: photometry: spectrophotometry: spectrophotometry, infrared research

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Strongly emissive individual DNA-encapsulated Ag nanoclusters as single-molecule fluorophores. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 12616-21

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 22

MONTH: 05

YEAR: 2007

Strongly emissive individual DNA-encapsulated Ag nanoclusters as single-molecule fluorophores. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Strongly emissive individual DNA-encapsulated Ag nanoclusters as single-molecule fluorophores. Keywords Mesh Terms:

KEYWORDS: Spectrophotometry, Infrared

MESH TERMS: chemistry

Chemical & Substance for Abstract: Strongly emissive individual DNA-encapsulated Ag nanoclusters as single-molecule fluorophores. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Strongly emissive individual DNA-encapsulated Ag nanoclusters as single-molecule fluorophores.

AFFILIATION: School of Chemistry and Biochemistry and Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332-0400, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01 GM 68732

ACRONYM: GM

MEDLINETA: Proc Natl Acad Sci U S A

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