Strong static magnetic field stimulates bone formation to a definite orientation in vitro and in vivo.

Strong static magnetic field stimulates bone formation to a definite orientation in vitro and in vivo. Research Abstract Details 

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Strong static magnetic field stimulates bone formation to a definite orientation in vitro and in vivo. Abstract Text:

Hiroko Kotani,Hiroshi Kawaguchi,Takashi Shimoaka,Masakazu Iwasaka,Shoogo Ueno,Hidehiro Ozawa,Kozo Nakamura,Kazuto Hoshi,

The induction of bone formation to an intentional orientation is a potentially viable clinical treatment for bone disorders. Among the many chemical and physical factors, a static magnetic field (SMF) of tesla order can regulate the shapes of blood cells and matrix fibers. This study investigated the effects of a strong SMF (8 T) on bone formation in both in vivo and in vitro systems. After 60 h of exposure to the SMF, cultured mouse osteoblastic MC3T3-E1 cells were transformed to rodlike shapes and were orientated in the direction parallel to the magnetic field. Although this strong SMF exposure did not affect cell proliferation, it up-regulated cell differentiation and matrix synthesis as determined by ALP and alizarin red stainings, respectively. The SMF also stimulated ectopic bone formation in and around subcutaneously implanted bone morphogenetic protein (BMP) 2-containing pellets in mice, in which the orientation of bone formation was parallel to the magnetic field. It is concluded that a strong SMF has the potency not only to stimulate bone formation, but also to regulate its orientation in both in vitro and in vivo models. This is the first study to show the regulation of the orientation of adherent cells by a magnetic field. We propose that the combination of a strong SMF and a potent osteogenic agent such as BMP possibly may lead to an effective treatment of bone fractures and defects.

Strong static magnetic field stimulates bone formation to a definite orientation in vitro and in vivo. Publishing Authors By Initials

H Kotani,H Kawaguchi,T Shimoaka,M Iwasaka,S Ueno,H Ozawa,K Nakamura,K Hoshi,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Strong static magnetic field stimulates bone formation to a definite orientation in vitro and in vivo. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of bone and mineral research : the officia

VOLUME: 17

Page Numbers: 1814-21

Journal Abbreviation: J. Bone Miner. Res.

ISSN: 0884-0431

DAY: 19

MONTH: Oct

YEAR: 2002

Strong static magnetic field stimulates bone formation to a definite orientation in vitro and in vivo. Information

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LANGUAGE: eng

NlmUniqueID: 8610640

Strong static magnetic field stimulates bone formation to a definite orientation in vitro and in vivo. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Strong static magnetic field stimulates bone formation to a definite orientation in vitro and in vivo. Information

Substance Name: Alkaline Phosphatase

Registry Number: EC 3.1.3.1

Grant and Affiliation Information for Strong static magnetic field stimulates bone formation to a definite orientation in vitro and in vivo.

AFFILIATION: Department of Biomedical Engineering, Graduate School of Medicine, University of Tokyo, Japan.

Country: United States

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MEDLINETA: J Bone Miner Res

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