Strong, macroporous, and in situ-setting calcium phosphate cement-layered structures.

Strong, macroporous, and in situ-setting calcium phosphate cement-layered structures. Research Abstract Details 

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Strong, macroporous, and in situ-setting calcium phosphate cement-layered structures. Abstract Text:

Hockin H K Xu,Elena F Burguera,Lisa E Carey,

Calcium phosphate cement (CPC) is highly promising for clinical uses due to its in situ-setting ability, excellent osteoconductivity and bone-replacement capability. However, the low strength limits its use to non-load-bearing applications. The objectives of this study were to develop a layered CPC structure by combining a macroporous CPC layer with a strong CPC layer, and to investigate the effects of porosity and layer thickness ratios. The rationale was for the macroporous layer to accept tissue ingrowth, while the fiber-reinforced strong layer would provide the needed early-strength. A biopolymer chitosan was incorporated to strengthen both layers. Flexural strength, S (mean+/-sd; n=6) of CPC-scaffold decreased from (9.7+/-1.2) to (1.8+/-0.3) MPa (p<0.05), when the porosity increased from 44.6% to 66.2%. However, with a strong-layer reinforcement, S increased to (25.2+/-6.7) and (10.0+/-1.4) MPa, respectively, at these two porosities. These strengths matched/exceeded the reported strengths of sintered porous hydroxyapatite implants and cancellous bone. Relationships were established between S and the ratio of strong layer thickness/specimen thickness, a/h:S=(17.6 a/h+3.2) MPa. The scaffold contained macropores with a macropore length (mean+/-sd; n=147) of (183+/-73) microm, suitable for cell infiltration and tissue ingrowth. Nano-sized hydroxyapatite crystals were observed to form the scaffold matrix of CPC with chitosan. In summary, a layered CPC implant, combining a macroporous CPC with a strong CPC, was developed. Mechanical strength and macroporosity are conflicting requirements. However, the novel functionally graded CPC enabled a relatively high strength and macroporosity to be simultaneously achieved. Such an in situ-hardening nano-apatite may be useful in moderate stress-bearing applications, with macroporosity to enhance tissue ingrowth and implant resorption.

Strong, macroporous, and in situ-setting calcium phosphate cement-layered structures. Publishing Authors By Initials

HH Xu,EF Burguera,LE Carey,

For similar biomechanics: tensile strength research abstracts see: biomechanics: tensile strength research

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Strong, macroporous, and in situ-setting calcium phosphate cement-layered structures. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biomaterials

VOLUME: 28

Page Numbers: 3786-96

Journal Abbreviation: Biomaterials

ISSN: 0142-9612

DAY: 26

MONTH: 05

YEAR: 2007

Strong, macroporous, and in situ-setting calcium phosphate cement-layered structures. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8100316

Strong, macroporous, and in situ-setting calcium phosphate cement-layered structures. Keywords Mesh Terms:

KEYWORDS: Tensile Strength

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Strong, macroporous, and in situ-setting calcium phosphate cement-layered structures. Information

Substance Name: Chitosan

Registry Number: 9012-76-4

Grant and Affiliation Information for Strong, macroporous, and in situ-setting calcium phosphate cement-layered structures.

AFFILIATION: Paffenbarger Research Center, American Dental Association Foundation, National Institute of Standards and Technology, 100 Bureau Drive Stop 8546, Gaithersburg, MD 20899-8546, USA. hockin.xu@nist.gov

Country: England

AGENCY: United States NIDCR

GRANT: DE14190

ACRONYM: DE

MEDLINETA: Biomaterials

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