Stromal metalloproteinase-9 is essential to angiogenesis and progressive growth of orthotopic human pancreatic cancer in parabiont nude mice.

Stromal metalloproteinase-9 is essential to angiogenesis and progressive growth of orthotopic human pancreatic cancer in parabiont nude mice. Research Abstract Details 

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Stromal metalloproteinase-9 is essential to angiogenesis and progressive growth of orthotopic human pancreatic cancer in parabiont nude mice. Abstract Text:

Toru Nakamura,Toshio Kuwai,Jang-Seong Kim,Dominic Fan,Sun-Jin Kim,Isaiah J Fidler,Toru Nakamura,Toshio Kuwai,Jang-Seong Kim,Dominic Fan,Sun-Jin Kim,Isaiah J Fidler,

We determined whether host matrix metalloproteinase (MMP) 9 is essential to angiogenesis and to the growth of L3.6pl human pancreatic cancer cells implanted into the pancreas of wild-type (MMP-9(+/+)) and knockout (MMP-9(-/-)) nude mice. Four weeks after tumor cell injection, pancreatic tumors in MMP-9(+/+) mice were large, had many blood vessels, and contained many macrophages expressing MMP-9. In contrast, pancreatic tumors in MMP-9(-/-) mice were significantly smaller, had few blood vessels, and had few macrophages. Next, we parabiosed MMP-9(+/+) mice with MMP-9(+/+) mice, MMP-9(-/-) mice with MMP-9(-/-) mice, and MMP-9(+/+) mice with MMP-9(-/-) mice. Two weeks after parabiosis, we implanted L3.6pl cells into the pancreas of the recipient mouse in each pair. Four weeks later, the mice were necropsied. The parabiosis experiment revealed a direct correlation between intratumoral MMP-9(+/+) expressing macrophages, angiogenesis, and progressive tumor growth. Because the expression of MMP-9 by L3.6pl tumor cells was similar in all parabionts, the data clearly demonstrate a major role for host-derived MMP-9 in angiogenesis and in the growth of human pancreatic cancer in the pancreas of nude mice.

Stromal metalloproteinase-9 is essential to angiogenesis and progressive growth of orthotopic human pancreatic cancer in parabiont nude mice. Publishing Authors By Initials

T Nakamura,T Kuwai,JS Kim,D Fan,SJ Kim,IJ Fidler,T Nakamura,T Kuwai,JS Kim,D Fan,SJ Kim,IJ Fidler,

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Stromal metalloproteinase-9 is essential to angiogenesis and progressive growth of orthotopic human pancreatic cancer in parabiont nude mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neoplasia (New York, N.Y.)

VOLUME: 9

Page Numbers: 979-86

Journal Abbreviation: Neoplasia

ISSN: 1476-5586

DAY: 21

MONTH: Nov

YEAR: 2007

Stromal metalloproteinase-9 is essential to angiogenesis and progressive growth of orthotopic human pancreatic cancer in parabiont nude mice. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Stromal metalloproteinase-9 is essential to angiogenesis and progressive growth of orthotopic human pancreatic cancer in parabiont nude mice.

AFFILIATION: Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77230-1429, USA.

Country: Canada

AGENCY: United States NCI

GRANT: CA90270

ACRONYM: CA

MEDLINETA: Neoplasia

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