Stromal-derived factor 1 signalling regulates radial and tangential migration in the developing cerebral cortex.

Stromal-derived factor 1 signalling regulates radial and tangential migration in the developing cerebral cortex. Research Abstract Details 

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Stromal-derived factor 1 signalling regulates radial and tangential migration in the developing cerebral cortex. Abstract Text:

Anastasia Liapi,James Pritchett,Owen Jones,Nobutaka Fujii,John G Parnavelas,Bagirathy Nadarajah,Anastasia Liapi,James Pritchett,Owen Jones,Nobutaka Fujii,John G Parnavelas,Bagirathy Nadarajah,Anastasia Liapi,James Pritchett,Owen Jones,Nobutaka Fujii,John G Parnavelas,Bagirathy Nadarajah,

Stromal-derived factor 1 (SDF-1), a known chemoattractant, and its receptor CXCR4 are widely expressed in the developing and adult cerebral cortex. Recent studies have highlighted potential roles for SDF-1 during early cortical development. In view of the current findings, our histological analysis has revealed a distinct pattern of SDF-1 expression in the developing cerebral cortex at a time when cell proliferation and migration are at peak. To determine the role of chemokine signalling during early cortical development, embryonic rat brain slices were exposed to a medium containing secreted SDF-1 to perturb the endogenous levels of chemokine. Alternatively, brain slices were treated with 40 muM of T140 or AMD3100, known antagonists of CXCR4. Using these experimental approaches, we demonstrate that chemokine signalling is imperative for the maintenance of the early cortical plate. In addition, we provide evidence that both neurogenesis and radial migration are concomitantly regulated by this signalling system. Conversely, interneurons, although not dependent on SDF-1 signalling to transgress the telencephalic boundary, require the chemokine to maintain their tangential migration. Collectively, our results demonstrate that SDF-1 with its distinct pattern of expression is essential and uniquely positioned to regulate key developmental events that underlie the formation of the cerebral cortex.

Stromal-derived factor 1 signalling regulates radial and tangential migration in the developing cerebral cortex. Publishing Authors By Initials

A Liapi,J Pritchett,O Jones,N Fujii,JG Parnavelas,B Nadarajah,A Liapi,J Pritchett,O Jones,N Fujii,JG Parnavelas,B Nadarajah,A Liapi,J Pritchett,O Jones,N Fujii,JG Parnavelas,B Nadarajah,

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Stromal-derived factor 1 signalling regulates radial and tangential migration in the developing cerebral cortex. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental neuroscience

VOLUME: 30

Page Numbers: 117-31

Journal Abbreviation: Dev. Neurosci.

ISSN: 1421-9859

DAY: 13

MONTH: 12

YEAR: 2008

Stromal-derived factor 1 signalling regulates radial and tangential migration in the developing cerebral cortex. Information

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LANGUAGE: eng

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AFFILIATION: Department of Anatomy and Developmental Biology, University College London, London, UK.

Country: Switzerland

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MEDLINETA: Dev Neurosci

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