Stromal-derived factor-1 and inflammatory cytokines in retinal vein occlusion.

Stromal-derived factor-1 and inflammatory cytokines in retinal vein occlusion. Research Abstract Details 

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Stromal-derived factor-1 and inflammatory cytokines in retinal vein occlusion. Abstract Text:

Yuya Ki-I,Noboru Arimura,Yoshihiro Noda,Keita Yamakiri,Norihito Doi,Teruto Hashiguchi,Ikuro Maruyama,Masahiko Shimura,Taiji Sakamoto,Yuya Ki-I,Noboru Arimura,Yoshihiro Noda,Keita Yamakiri,Norihito Doi,Teruto Hashiguchi,Ikuro Maruyama,Masahiko Shimura,Taiji Sakamoto,Yuya Ki-I,Noboru Arimura,Yoshihiro Noda,Keita Yamakiri,Norihito Doi,Teruto Hashiguchi,Ikuro Maruyama,Masahiko Shimura,Taiji Sakamoto,Yuya Ki-I,Noboru Arimura,Yoshihiro Noda,Keita Yamakiri,Norihito Doi,Teruto Hashiguchi,Ikuro Maruyama,Masahiko Shimura,Taiji Sakamoto,

Purpose: To identify the roles of stromal-derived factor (SDF-1) and inflammatory cytokines in retinal vein occlusion (RVO). Methods: Samples were collected by vitrectomy and the levels of SDF-1, vascular endothelial growth factor, and inflammatory cytokines (interleukins [IL-1beta, IL-6, IL-8, IL-10, IL-12p70]; tumor necrosis factor-alpha) were measured in 20 eyes with RVO, and 9 eyes with epiretinal membrane served as negative controls. Four eyes with inflammatory diseases were also investigated. Results: SDF-1 levels in active RVO (A-RVO; 4 eyes with iris neovascularization) were significantly higher than those in quiescent RVO (Q-RVO; 16 eyes without iris neovascularization) and the negative controls (p < .01), whereas there were no significant difference between the Q-RVO and the negative controls. There were no significant correlations between the concentrations of SDF-1 and other cytokines. Conclusions: Elevation of intravitreous SDF-1 levels in A-RVO but not Q-RVO suggested a pivotal role of SDF-1 in angiogenic changes during RVO.

Stromal-derived factor-1 and inflammatory cytokines in retinal vein occlusion. Publishing Authors By Initials

Y Ki-I,N Arimura,Y Noda,K Yamakiri,N Doi,T Hashiguchi,I Maruyama,M Shimura,T Sakamoto,Y Ki-I,N Arimura,Y Noda,K Yamakiri,N Doi,T Hashiguchi,I Maruyama,M Shimura,T Sakamoto,Y Ki-I,N Arimura,Y Noda,K Yamakiri,N Doi,T Hashiguchi,I Maruyama,M Shimura,T Sakamoto,Y Ki-I,N Arimura,Y Noda,K Yamakiri,N Doi,T Hashiguchi,I Maruyama,M Shimura,T Sakamoto,

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Stromal-derived factor-1 and inflammatory cytokines in retinal vein occlusion. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current eye research

VOLUME: 32

Page Numbers: 1065-72

Journal Abbreviation: Curr. Eye Res.

ISSN: 0271-3683

DAY: 18

MONTH: Dec

YEAR: 2007

Stromal-derived factor-1 and inflammatory cytokines in retinal vein occlusion. Information

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LANGUAGE: eng

NlmUniqueID: 8104312

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AFFILIATION: Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Country: England

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MEDLINETA: Curr Eye Res

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