Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus.

Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus. Abstract Text:

Amrita Nair,Krishna C Vadodaria,Sunayana B Banerjee,Madhurima Benekareddy,Brian G Dias,Ronald S Duman,Vidita A Vaidya,

Stress regulation of brain-derived neurotrophic factor (BDNF) is implicated in the hippocampal damage observed in depression. BDNF has a complex gene structure with four 5' untranslated exons (I-IV) with unique promoters, and a common 3' coding exon (V). To better understand the stress regulation of BDNF, we addressed whether distinct stressors differentially regulate exon-specific BDNF transcripts in the postnatal and adult hippocampus. The early life stress of maternal separation (MS) resulted in a time point-dependent differential upregulation of BDNF transcripts restricted to early postnatal life (P14-BDNF II, P21-BDNF IV, V). In adulthood, distinct stressors regulated BDNF transcripts in a signature manner. Immobilization stress, administered once, decreased all BDNF splice variants but had differing effects on BDNF I/II (increase) and III/IV (decrease) when administered chronically. Although immobilization stress reduced BDNF (V) mRNA, chronic unpredictable stress did not influence total BDNF despite altering specific BDNF transcripts. Furthermore, a prior history of MS altered the signature pattern in which adult-onset stress regulated specific BDNF transcripts. We also examined the expression of cyclic AMP response element-binding protein (CREB), an upstream transcriptional activator of BDNF, and observed a CREB induction in the postnatal hippocampus following MS. As a possible consequence of enhanced CREB and BDNF expression following MS, we examined hippocampal progenitor proliferation and observed a significant increase restricted to early life. These results suggest that alterations in CREB/BDNF may contribute to the generation of individual differences in stress neurocircuitry, providing a substrate for altered vulnerability to depressive disorders.

Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus. Publishing Authors By Initials

A Nair,KC Vadodaria,SB Banerjee,M Benekareddy,BG Dias,RS Duman,VA Vaidya,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

PUBMED ID PMID:

MEDLINE DATE:

Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neuropsychopharmacology : official publication of

VOLUME: 32

Page Numbers: 1504-19

Journal Abbreviation: Neuropsychopharmacology

ISSN: 0893-133X

DAY: 13

MONTH: 12

YEAR: 2006

Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8904907

Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: physiology

Chemical & Substance for Abstract: Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus. Information

Substance Name: RNA, Messenger

Registry Number: 0

Grant and Affiliation Information for Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus.

AFFILIATION: Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.

Country: United States

AGENCY: United States FIC

GRANT: 1R03 TW 006257-01

ACRONYM: TW

MEDLINETA: Neuropsychopharmacology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus Related Publications

• A POINT IN FAVOUR OF PROFESSOR ARTHUR THOMSON'S THEORY OF THE PRODUCTION OF GLAUCOMA.
• Acute renal failure secondary to oxalosis in a recipient of a simultaneous kidney-pancreas transplant: was mycophenolate the cause?
• Analysis of gross deletions in the MEN1 gene in patients with multiple endocrine neoplasia type 1.
• Anti-phospholipid antibody-mediated rejection.
• Antidepressant treatments regulate matrix metalloproteinases-2 and -9 (MMP-2/MMP-9) and tissue inhibitors of the metalloproteinases (TIMPS 1-4) in the adult rat hippocampus.
• Atypical neural substrates of Embedded Figures Task performance in children with Autism Spectrum Disorder.
• Biomechanical analysis of differing pedicle screw insertion angles.
• Carpopedal spasm in an elderly man: an unusual presentation of coeliac disease.
• Clinical importance of anti-human leukocyte antigen-specific antibody concentration in performing calculated panel reactive antibody and virtual crossmatches.
• Cocirculation of and coinfections with hepatitis A virus subgenotypes IIIA and IB in patients from Pune, western India.
• Development of a real-time polymerase chain reaction assay for the quantification of Leishmania species and the monitoring of systemic distribution of the pathogen.
• Developmental differences in cognitive control of socio-affective processing.
• Early antiretroviral therapy: The pendulum shifts again.
• Effects of atypical anxiolytic N-phenyl-2-[1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidine]acetamide (JNJ-5234801) on alcohol intake in alcohol-preferring P rats.
• Induction of autophagic cell death in Leishmania donovani by antimicrobial peptides.
• Influence of fluoride containing toothpaste on serum and urine fluoride levels in children.
• Mathematical modelling of radiotherapy strategies for early breast cancer.
• Method to test whether late extended letrozole, rather than self- selection, improves the outcome in patients with breast cancer who have completed 5 years of tamoxifen.
• Mitochondrial drug targets in apicomplexan parasites.
• Novel technologies for the discovery and quantitation of biomarkers of toxicity.
• Plasmodium vivax malaria in spite of atovaquone/proguanil (malarone) prophylaxis.
• Platelet Inhibition by Aspirin 81 and 325 mg/day in Men Versus Women Without Clinically Apparent Cardiovascular Disease.
• Platelet functional implications of glycoprotein Ibalpha polymorphisms in African Americans.
• Polymer platforms for drug delivery and biomedical imaging.
• Psychiatry Clerkship Objective Structured Clinical Examination is Here to Stay.
• Pyridine biodegradation in a novel rotating rope bioreactor.
• Racial differences of lipoprotein subclass distributions in postmenopausal women.
• Re: Declines in invasive breast cancer and use of postmenopausal hormone therapy in a screening mammography population.
• Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus.
• Vitamin D and cancer.