Stress sensitivity in metastatic breast cancer: analysis of hypothalamic-pituitary-adrenal axis function.

Stress sensitivity in metastatic breast cancer: analysis of hypothalamic-pituitary-adrenal axis function. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Stress sensitivity in metastatic breast cancer: analysis of hypothalamic-pituitary-adrenal axis function. Abstract Text:

David Spiegel,Janine Giese-Davis,C Barr Taylor,Helena Kraemer,

The normal diurnal cortisol cycle has a peak in the morning, decreasing rapidly over the day, with low levels during the night, then rising rapidly again to the morning peak. A pattern of flatter daytime slopes has been associated with more rapid cancer progression in both animals and humans. We studied the relationship between the daytime slopes and other daytime cortisol responses to both pharmacological and psychosocial challenges of hypothalamic-pituitary-adrenal (HPA) axis function as well as DHEA in a sample of 99 women with metastatic breast cancer, in hopes of elucidating the dysregulatory process. We found that the different components of HPA regulation: the daytime cortisol slope, the rise in cortisol from waking to 30 min later, and cortisol response to various challenges, including dexamethasone (DEX) suppression, corticotrophin releasing factor (CRF) activation, and the Trier Social Stress Task, were at best modestly associated. Escape from suppression stimulated by 1mg of DEX administered the night before was moderately but significantly associated with flatter daytime cortisol slopes (r=0.28 to .30 at different times of the post DEX administration day, all p<.01). Daytime cortisol slopes were also moderately but significant associated with the rise in cortisol from waking to 30 min after awakening (r=.29, p=.004, N=96), but not with waking cortisol level (r=-0.13, p=.19). However, we could not detect any association between daytime cortisol slope and activation of cortisol secretion by either CRF infusion or the Trier Social Stress Task. The CRF activation test (following 1.5mg of DEX to assure that the effect was due to exogenous CRF) produced ACTH levels that were correlated (r=0.66, p<.0001, N=74) with serum cortisol levels, indicating adrenal responsiveness to ACTH stimulation. Daytime cortisol slopes were significantly correlated with the slope of DHEA (r=.21, p=.04, N=95). Our general findings suggest that flatter daytime cortisol slopes among metastatic breast cancer patients may be related to disrupted feedback inhibition rather than hypersensitivity in response to stimulation.

Stress sensitivity in metastatic breast cancer: analysis of hypothalamic-pituitary-adrenal axis function. Publishing Authors By Initials

D Spiegel,J Giese-Davis,CB Taylor,H Kraemer,

For similar pathological conditions, signs and symptoms: pathologic processes: stress research abstracts see: pathological conditions, signs and symptoms: pathologic processes: stress research

PUBMED ID PMID:

MEDLINE DATE:

Stress sensitivity in metastatic breast cancer: analysis of hypothalamic-pituitary-adrenal axis function. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Psychoneuroendocrinology

VOLUME: 31

Page Numbers: 1231-44

Journal Abbreviation: Psychoneuroendocrinology

ISSN: 0306-4530

DAY: 1

MONTH: 11

YEAR: 2006

Stress sensitivity in metastatic breast cancer: analysis of hypothalamic-pituitary-adrenal axis function. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7612148

Stress sensitivity in metastatic breast cancer: analysis of hypothalamic-pituitary-adrenal axis function. Keywords Mesh Terms:

KEYWORDS: Stress

MESH TERMS: etiology

Chemical & Substance for Abstract: Stress sensitivity in metastatic breast cancer: analysis of hypothalamic-pituitary-adrenal axis function. Information

Substance Name: Adrenocorticotropic Hormone

Registry Number: 9002-60-2

Grant and Affiliation Information for Stress sensitivity in metastatic breast cancer: analysis of hypothalamic-pituitary-adrenal axis function.

AFFILIATION: Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5718, USA. dspiegel@stanford.edu

Country: England

AGENCY: United States NIA

GRANT: P01 AG018784-05

ACRONYM: AG

MEDLINETA: Psychoneuroendocrinology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Stress sensitivity in metastatic breast cancer: analysis of hypothalamic-pituitary-adrenal axis function Related Publications

• A message from the editor-in-chief.
• A new brief instrument for assessing decisional capacity for clinical research.
• Assessment of canine oocyte viability after transportation and storage under different conditions.
• Childhood risk factors for thin body preoccupation and social pressure to be thin.
• Comments on 'Evaluating the added predictive ability of a new marker' by M. Pencina, R. D'Agostino, R. D'Agostino Jr, R. Vasan, Statistics in Medicine (DOI: 10.1002/sim.2929).
• Copper(II)-quenched oligonucleotide probes for fluorescent DNA sensing.
• Cost analysis of Jelonet((R)) versus Suprathel((R)) in the management of split-thickness skin graft donor sites.
• DNA-templated metal catalysis.
• Distribution of a triphosphopyridine nucleotide-specific enzyme catalyzing the reversible oxidative decarboxylation of malic acid in higher plants.
• Early pregnancy diagnosis by transrectal ultrasonography in dairy cattle.
• Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial.
• Effects of Muscle ArmorTM Supplementation During a Resistance Training Program on Body Composition and Performance Outcomes In Men: 1587: Board #77 May 30 3:30 PM - 5:00 PM.
• Effects of inhibitors of protein and RNA synthesis on regeneration of surface sialic acid of cells in culture. LA-3610-MS.
• Effects of supportive-expressive group therapy on survival of patients with metastatic breast cancer: a randomized prospective trial.
• Generation of novel adipocyte monolayer cultures from embryonic stem cells.
• Growth inhibition of MCF-7 tumor cell line by phenylacetate linked to functionalized dextran.
• Interaction of rat hormone-sensitive lipase with adipocyte lipid-binding protein.
• Intracranial intrasellar kissing carotid arteries: case report.
• Long-term effects of mnemonic training in community-dwelling older adults.
• Methods for collecting follicular oocytes from mares.
• Nonsurgical recovery of degenerative ova from the uteri of mares.
• Resistance Training, But Not Aerobic Exercise Training Attenuates The IGFBP-1 Response To Acute Resistance Exercise: 770: May 31 3:45 PM 4:00 PM.
• Stress sensitivity in metastatic breast cancer: analysis of hypothalamic-pituitary-adrenal axis function.
• The cost-effectiveness and cost-benefit of screening and brief intervention for unhealthy alcohol use in medical settings.
• The metabolism and effects of contraceptive steroids in primates.
• Vascular endothelial growth factor-C and its receptor VEGFR-3 in non-small-cell lung cancer: concurrent expression in cancer cells from primary tumour and metastatic lymph node.
• Ventilation inhomogeneities assessed by the multibreath washout (MBW) technique.
• Xeroderma pigmentosum. A prototype disease of environmental-genetic interaction.
• [Acute asthma attack in children]
• [Etiopathogenetic aspects of allergic pulmonary diseases in childhood]