Stress-related sleep disturbance and polysomnographic response to caffeine.

Stress-related sleep disturbance and polysomnographic response to caffeine. Research Abstract Details 

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Stress-related sleep disturbance and polysomnographic response to caffeine. Abstract Text:

Christopher L Drake,Catherine Jefferson,Timothy Roehrs,Thomas Roth,

BACKGROUND AND PURPOSE: To determine the sleep response to caffeine in individuals vulnerable to stress-related sleep disturbance as measured by polysomnography. PATIENTS AND METHODS: Eleven healthy individuals without insomnia scoring low (4 women, mean age=32.64+/-15.46 years) and 10 healthy individuals also without insomnia scoring high (6 women, mean age=34.20+/-13.73 years) on a measure of vulnerability to stress-related sleep disturbance were studied in a laboratory protocol. A moderate-low dose of caffeine (3 mg/kg) was administered 1h prior to lights-out and compared to a counterbalanced control night with each condition separated by 1 week. Standard polysomnographic measures were assessed (i.e. total sleep time, sleep efficiency, latency to persistent sleep, and sleep stage percentages) for both control and caffeine nights. RESULTS: There were no between-group differences in sleep on the control night. Importantly, individuals reporting vulnerability to stress-related sleep disturbance had significantly prolonged latency to persistent sleep in response to the caffeine challenge (interaction; P<0.05). CONCLUSION: Normal sleepers with an identified vulnerability to stress-induced sleep disturbance exhibited greater objectively verifiable sleep-reactivity in response to a caffeine challenge compared to non-vulnerable individuals. These results suggest that the construct of individual differences in vulnerability to sleep disturbance applies to a pharmacological 'stressor' (i.e. caffeine) as well as to previously assessed stressors such as a first-night effect. This finding provides further support for generalized trait vulnerability by demonstrating a sleep disturbance to a wake-promoting pharmacological challenge in specific a priori identified individuals.

Stress-related sleep disturbance and polysomnographic response to caffeine. Publishing Authors By Initials

CL Drake,C Jefferson,T Roehrs,T Roth,

For similar behavior and behavior mechanisms: behavior: behavioral symptoms: stress, psychological research abstracts see: behavior and behavior mechanisms: behavior: behavioral symptoms: stress, psychological research

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Stress-related sleep disturbance and polysomnographic response to caffeine. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Sleep medicine

VOLUME: 7

Page Numbers: 567-72

Journal Abbreviation: Sleep Med.

ISSN: 1389-9457

DAY: 22

MONTH: 09

YEAR: 2006

Stress-related sleep disturbance and polysomnographic response to caffeine. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100898759

Stress-related sleep disturbance and polysomnographic response to caffeine. Keywords Mesh Terms:

KEYWORDS: Stress, Psychological

MESH TERMS: complications

Chemical & Substance for Abstract: Stress-related sleep disturbance and polysomnographic response to caffeine. Information

Substance Name: Caffeine

Registry Number: 58-08-2

Grant and Affiliation Information for Stress-related sleep disturbance and polysomnographic response to caffeine.

AFFILIATION: Henry Ford Hospital Sleep Disorders and Research Center, and Department of Psychiatry and Behavioral Neurosciences, Wayne State College of Medicine, Detroit, MI 48202, USA. cdrake1@hfhs.org

Country: Netherlands

AGENCY: United States NIMH

GRANT: MH68372

ACRONYM: MH

MEDLINETA: Sleep Med

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