Stress-induced secretion of ACTH and corticosterone during development of spontaneous hypertension in rats.

Stress-induced secretion of ACTH and corticosterone during development of spontaneous hypertension in rats. Research Abstract Details 

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Stress-induced secretion of ACTH and corticosterone during development of spontaneous hypertension in rats. Abstract Text:

A Häusler,J Girard,J B Baumann,W Ruch,U H Otten,

Plasma ACTH and corticosterone response to ether inhalation was examined in spontaneously hypertensive rats (SHR) and in normotensive Wistar-Kyoto (WKY) and Wistar control rats at 4, 8, 12 and 16 weeks of age. In SHR, blood pressure rose to hypertensive levels (above 150 mm Hg) between 5 and 8 weeks, whereas, in control animals, it did not exceed 140 mm Hg. Maximum plasma ACTH concentrations were measured 5 min after exposure to ether and plasma corticosterone values attained their maximum at 20 min. Stress-induced ACTH release was significantly elevated in SHR at 4 and 8 weeks. At 16 weeks of age, no difference in the ACTH response between the three strains could be detected. Correspondingly, 4-week-old SHR showed a more pronounced corticosterone release than Wistar and WKY, whereas 16-week-old SHR and control rats responded similarly. Hypothalamo-pituitary-adrenocortical response to ether stress is thus markedly enhanced in SHR during early development of hypertension.

Stress-induced secretion of ACTH and corticosterone during development of spontaneous hypertension in rats. Publishing Authors By Initials

A Häusler,J Girard,JB Baumann,W Ruch,UH Otten,

For similar pathological conditions, signs and symptoms: pathologic processes: stress research abstracts see: pathological conditions, signs and symptoms: pathologic processes: stress research

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Stress-induced secretion of ACTH and corticosterone during development of spontaneous hypertension in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 5

Page Numbers: 11-9

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1983

Stress-induced secretion of ACTH and corticosterone during development of spontaneous hypertension in rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8207790

Stress-induced secretion of ACTH and corticosterone during development of spontaneous hypertension in rats. Keywords Mesh Terms:

KEYWORDS: Stress

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Stress-induced secretion of ACTH and corticosterone during development of spontaneous hypertension in rats. Information

Substance Name: Adrenocorticotropic Hormone

Registry Number: 9002-60-2

Grant and Affiliation Information for Stress-induced secretion of ACTH and corticosterone during development of spontaneous hypertension in rats.

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Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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