Stress as a risk factor in the pathogenesis of rheumatoid arthritis.

Stress as a risk factor in the pathogenesis of rheumatoid arthritis. Research Abstract Details 

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Stress as a risk factor in the pathogenesis of rheumatoid arthritis. Abstract Text:

Maurizio Cutolo,Rainer H Straub,

Stress is now recognized as an important risk factor in the pathogenesis of autoimmune rheumatic diseases (i.e. rheumatoid arthritis) by considering that the activation of the stress response system influences the close relationships existing between the hypothalamic-pituitary-adrenal axis, the sympathetic nervous system and the immune system. The stress response results in the release of neurotransmitters (norepinephrine), hormones (cortisol) and immune cells which serve to send an efferent message from the brain to the periphery. Major life events lead to an intense release of stress mediators (large time integral of released neurotransmitters and hormones), whereas in minor life events, only short-lived surges of neurotransmitters and hormones are expected. Therefore, it is suggested that neurotransmitters such as norepinephrine or stress hormones such as cortisol might have different effects on immune/inflammatory responses at high and low concentrations present during short or extended periods of time, respectively. Long-lasting (chronic) stress may lead to proinflammatory effects because no adequate long-term responses of stress axes (anti-inflammatory) are to be expected.

Stress as a risk factor in the pathogenesis of rheumatoid arthritis. Publishing Authors By Initials

M Cutolo,RH Straub,

For similar behavior and behavior mechanisms: behavior: behavioral symptoms: stress, psychological research abstracts see: behavior and behavior mechanisms: behavior: behavioral symptoms: stress, psychological research

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Stress as a risk factor in the pathogenesis of rheumatoid arthritis. Journal Published:

PUBLICATION TYPE: Review

Journal: Neuroimmunomodulation

VOLUME: 13

Page Numbers: 277-82

Journal Abbreviation: Neuroimmunomodulation

ISSN: 1021-7401

DAY: 6

MONTH: 08

YEAR: 2007

Stress as a risk factor in the pathogenesis of rheumatoid arthritis. Information

Number of References: 42

LANGUAGE: eng

NlmUniqueID: 9422763

Stress as a risk factor in the pathogenesis of rheumatoid arthritis. Keywords Mesh Terms:

KEYWORDS: Stress, Psychological

MESH TERMS: immunology

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Grant and Affiliation Information for Stress as a risk factor in the pathogenesis of rheumatoid arthritis.

AFFILIATION: Research Laboratory and Academic Clinical Unit of Rheumatology, Department of Internal Medicine, University of Genoa, Italy, and Department of Internal Medicine I, University Hospital, Regensburg, Germany. mcutolo@unige.it

Country: Switzerland

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MEDLINETA: Neuroimmunomodulation

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