Streptomyces coelicolor genes ftsL and divIC play a role in cell division but are dispensable for colony formation.

Streptomyces coelicolor genes ftsL and divIC play a role in cell division but are dispensable for colony formation. Research Abstract Details 

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Streptomyces coelicolor genes ftsL and divIC play a role in cell division but are dispensable for colony formation. Abstract Text:

Jennifer A Bennett,Rachel M Aimino,Joseph R McCormick,Jennifer A Bennett,Rachel M Aimino,Joseph R McCormick,Jennifer A Bennett,Rachel M Aimino,Joseph R McCormick,

We have characterized homologues of the bacterial cell division genes ftsL and divIC in the gram-positive mycelial bacterium Streptomyces coelicolor A3(2). We show by deletion-insertion mutations that ftsL and divIC are dispensable for growth and viability in S. coelicolor. When mutant strains were grown on a conventional rich medium (R2YE, containing high sucrose), inactivation of either ftsL or divIC resulted in the formation of aerial hyphae with partially constricted division sites but no clear separation of prespore compartments. Surprisingly, this phenotype was largely suppressed when strains were grown on minimal medium or sucrose-free R2YE, where division sites in many aerial hyphae had finished constricting and chains of spores were evident. Thus, osmolarity appears to affect the severity of the division defect. Furthermore, double mutant strains deleted for both ftsL and divIC are viable and have medium-dependent phenotypes similar to that of the single mutant strains, suggesting that functions performed by FtsL and DivIC are not absolutely required for septation during growth and sporulation. Alternatively, another division protein may partially compensate for the loss of both FtsL and DivIC on minimal medium or sucrose-free R2YE. Finally, based on transmission electron microscopy observations, we propose that FtsL and DivIC are involved in coordinating symmetrical annular ingrowth of the invaginating septum.

Streptomyces coelicolor genes ftsL and divIC play a role in cell division but are dispensable for colony formation. Publishing Authors By Initials

JA Bennett,RM Aimino,JR McCormick,JA Bennett,RM Aimino,JR McCormick,JA Bennett,RM Aimino,JR McCormick,

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Streptomyces coelicolor genes ftsL and divIC play a role in cell division but are dispensable for colony formation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of bacteriology

VOLUME: 189

Page Numbers: 8982-92

Journal Abbreviation: J. Bacteriol.

ISSN: 1098-5530

DAY: 19

MONTH: 10

YEAR: 2007

Streptomyces coelicolor genes ftsL and divIC play a role in cell division but are dispensable for colony formation. Information

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LANGUAGE: eng

NlmUniqueID: 2985120

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Grant and Affiliation Information for Streptomyces coelicolor genes ftsL and divIC play a role in cell division but are dispensable for colony formation.

AFFILIATION: Department of Biological Sciences, Duquesne University, Pittsburgh, PA 15282, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM56915

ACRONYM: GM

MEDLINETA: J Bacteriol

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