Streptococcus pneumoniae Deficient in Pneumolysin or Autolysin Has Reduced Virulence in Meningitis.

Streptococcus pneumoniae Deficient in Pneumolysin or Autolysin Has Reduced Virulence in Meningitis. Research Abstract Details 

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Streptococcus pneumoniae Deficient in Pneumolysin or Autolysin Has Reduced Virulence in Meningitis. Abstract Text:

Background. @nbsp; The role played by pneumolysin and autolysin in pneumococcal meningitis is poorly understood. Methods. @nbsp; A rat model was used to investigate the disease, in which surgical implantation of a cisternal catheter allowed bacterial instillation and cerebrospinal fluid (CSF) sampling. Results. @nbsp; CSF infection of rats with wild-type pneumococci caused meningitis within 26 h, whereas isogenic mutants that do not express pneumolysin (DeltaPly) or autolysin (LytA(-)) caused very mild or no disease. Wild-type infections resulted in pneumococci in the CSF and cortical homogenates, but a minority of the rats infected with DeltaPly or LytA(-) had bacteria in these locations at 26 h. Leukocyte numbers in the CSF were similar after infection with all pneumococci; however, neutrophils and monocytes predominated after wild-type infection, whereas lymphocytes and atypical lymphocytes predominated after infection with the mutants. Wild-type pneumococci caused disruption to the ependyma, but this was not observed in rats infected with DeltaPly or LytA(-). Cells surrounding the ventricles in wild type-infected animals expressed caspase 3, and astrocytes had hypertrophy; both findings were absent in rats infected with the mutants. Conclusions. @nbsp; This study provides strong in vivo evidence that pneumolysin and autolysin play crucial roles in the pathogenesis of pneumococcal meningitis.

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Streptococcus pneumoniae Deficient in Pneumolysin or Autolysin Has Reduced Virulence in Meningitis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of infectious diseases

VOLUME: 197

Page Numbers: 744-51

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 1

MONTH: Mar

YEAR: 2008

Streptococcus pneumoniae Deficient in Pneumolysin or Autolysin Has Reduced Virulence in Meningitis. Information

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LANGUAGE: eng

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AFFILIATION: 1Department of Infection, Immunity, and Inflammation and 2Medical Research Council Toxicology Unit, University of Leicester, Leicester, United Kingdom.

Country: United States

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MEDLINETA: J Infect Dis

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