Strain fidelity of chronic wasting disease upon murine adaptation.

Strain fidelity of chronic wasting disease upon murine adaptation. Research Abstract Details 

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Strain fidelity of chronic wasting disease upon murine adaptation. Abstract Text:

Christina J Sigurdson,Giuseppe Manco,Petra Schwarz,Pawel Liberski,Edward A Hoover,Simone Hornemann,Magdalini Polymenidou,Michael W Miller,Markus Glatzel,Adriano Aguzzi,

Chronic wasting disease (CWD), a prion disease of deer and elk, is highly prevalent in some regions of North America. The establishment of mouse-adapted CWD prions has proven difficult due to the strong species barrier between mice and deer. Here we report the efficient transmission of CWD to transgenic mice overexpressing murine PrP. All mice developed disease 500 +/- 62 days after intracerebral CWD challenge. The incubation period decreased to 228 +/- 103 days on secondary passage and to 162 +/- 6 days on tertiary passage. Mice developed very large, radially structured cerebral amyloid plaques similar to those of CWD-infected deer and elk. PrP(Sc) was detected in spleen, indicating that murine CWD was lymphotropic. PrP(Sc) glycoform profiles maintained a predominantly diglycosylated PrP pattern, as seen with CWD in deer and elk, across all passages. Therefore, all pathological, biochemical, and histological strain characteristics of CWD appear to persist upon repetitive serial passage through mice. These findings indicate that the salient strain-specific properties of CWD are encoded by agent-intrinsic components rather than by host factors.

Strain fidelity of chronic wasting disease upon murine adaptation. Publishing Authors By Initials

CJ Sigurdson,G Manco,P Schwarz,P Liberski,EA Hoover,S Hornemann,M Polymenidou,MW Miller,M Glatzel,A Aguzzi,

For similar prion diseases: wasting disease, chronic research abstracts see: prion diseases: wasting disease, chronic research

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Strain fidelity of chronic wasting disease upon murine adaptation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of virology

VOLUME: 80

Page Numbers: 12303-11

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 4

MONTH: 10

YEAR: 2006

Strain fidelity of chronic wasting disease upon murine adaptation. Information

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LANGUAGE: eng

NlmUniqueID: 113724

Strain fidelity of chronic wasting disease upon murine adaptation. Keywords Mesh Terms:

KEYWORDS: Wasting Disease, Chronic

MESH TERMS: transmission

Chemical & Substance for Abstract: Strain fidelity of chronic wasting disease upon murine adaptation. Information

Substance Name: Pregnancy Proteins

Registry Number: 0

Grant and Affiliation Information for Strain fidelity of chronic wasting disease upon murine adaptation.

AFFILIATION: UniversitätsSpital Zürich, Institute of Neuropathology, Department of Pathology, Schmelzbergstrasse 12, CH-8091 Zürich, Switzerland.

Country: United States

AGENCY: United States NIAID

GRANT: K08-AI01802

ACRONYM: AI

MEDLINETA: J Virol

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