Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine.

Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine. Research Abstract Details 

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Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine. Abstract Text:

Marc Lipsitch,Keith O'Neill,Derrick Cordy,Boris Bugalter,Krzysztof Trzcinski,Claudette M Thompson,Richard Goldstein,Stephen Pelton,Heather Huot,Valerie Bouchet,Raymond Reid,Mathuram Santosham,Katherine L O'Brien,

Widespread use of 7-valent pneumococcal conjugate vaccine (PCV7) has led to significant reductions in disease while changing pneumococcal population dynamics via herd immunity and serotype replacement. We performed multilocus sequence typing (MLST) on 590 pneumococcal isolates obtained during the American Indian clinical trial of PCV7, in which communities were randomized for eligible children to receive either PCV7 or a meningococcal conjugate vaccine (MCV). Sequence types (STs) were analyzed to determine the impact of the vaccine on pneumococcal population structure and to assess the possible impact of pneumococcal genetic background on vaccine effects. One hundred forty-three STs were obtained, the most frequent being ST199, the only one that included vaccine serotypes (VTs), non-vaccine-associated nonvaccine serotypes (NVA/NVTs), and vaccine-associated serotypes (VATs). Serotype replacement observed in the PCV communities was due to a diverse population of STs, most of which also existed in the MCV communities. Possible capsular switching to create novel ST associations with NVA/NVTs was detected only once. Reductions in VTs and changes in VATs in PCV communities did not show evidence of variation by ST, after accounting for lower vaccine effectiveness against serotype 19F. These observations suggest the hypothesis that the vaccine acts as a "serotype filter": its effect on a particular strain can be predicted on the basis of the serotype of the strain, with little effect of genetic background (as assessed by MLST) over and above capsule. If sustained, such patterns provide some cause for optimism that rapid evolution of PCV escape strains with drug resistance or high virulence is unlikely.

Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine. Publishing Authors By Initials

M Lipsitch,K O'Neill,D Cordy,B Bugalter,K Trzcinski,CM Thompson,R Goldstein,S Pelton,H Huot,V Bouchet,R Reid,M Santosham,KL O'Brien,

For similar vaccines, conjugate research abstracts see: vaccines, conjugate research

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Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of infectious diseases

VOLUME: 196

Page Numbers: 1221-7

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 17

MONTH: 09

YEAR: 2007

Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 413675

Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine. Keywords Mesh Terms:

KEYWORDS: Vaccines, Conjugate

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine. Information

Substance Name: heptavalent pneumococcal conjugate vacci

Registry Number: 0

Grant and Affiliation Information for Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine.

AFFILIATION: Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. mlipsitc@hsph.harvard.edu

Country: United States

AGENCY: United States NIAID

GRANT: 1R01AI48935

ACRONYM: AI

MEDLINETA: J Infect Dis

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